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Respiratory outcome...
Respiratory outcome after one-year treatment of obstructive sleep apnea with bibloc versus monobloc oral appliances : a multicenter, randomized equivalence trial
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- Tegelberg, Åke (författare)
- Malmö universitet,Odontologiska fakulteten (OD)
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- Nohlert, E. (författare)
- Centre for clinical research, Uppsala university, Västerås, Sweden
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- Bornefalk-Hermansson, A. (författare)
- Uppsala clinical research, Uppsala university, Uppsala, Sweden
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- Fransson, Anette M. C., 1954- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Postgraduate Dental Education Center and Faculty of medicine and health
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- Isacsson, G. (författare)
- Orofacial pain clinic and Centre for clinical research, Uppsala university, Västerås, Sweden
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- Engelska.
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Ingår i: Sleep Medicine. - : Elsevier. - 1389-9457 .- 1878-5506. ; 64:Suppl. 1, s. S378-S378
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: The benefit of bibloc over monobloc appliances in one-year obstructive sleep apnea (OSA) has not been evaluated in randomized trials. We hypothesized that these types of appliances are equally effective.Methods: In this multicenter, randomized equivalence trial patients with OSA were assigned to either bibloc or monobloc appliance treatment. At baseline a one-night home respiratory polygraphy was done without respiratory support, and at one-year follow-up examination iterated with the appliance in place. The outcome was the change in the apnea-hypopnea-index (AHI) and the equivalence limits were set at ±5.Results: Out of 302 patients 146 were randomly assigned to bibloc and 156 to monobloc. In 88 and 104 patients, respectively, were analysed per-protocol with a significant reduction of AHI with a mean change -16.7 (95% CI -19.4 to -14.1) in the bibloc and -11.8 (-14.9 to -8.7) in the monobloc and not significantly equivalent. The proportion of responders defined as AHI < 10 at the follow-up was 68% and 65% for bibloc and monobloc, respectively. Treatment related adverse events were generally mild and transient and occurred similar in frequencies between groups.Conclusions: Bibloc and monobloc appliance treatment gave a significant positive effect in treating OSA. The treatment modalities were not statistically equivalent, with a numerically greater reduction with bibloc, and, were associated with a similar degree of adverse events.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
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