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Maternal Influenza ...
Maternal Influenza A(H1N1) Immunization During Pregnancy and Risk for Autism Spectrum Disorder in Offspring
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- Ludvigsson, Jonas F., 1969- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Karolinska Institutet, Stockholm, Sweden; School of Medicine, University of Nottingham, Nottingham, United Kingdom; Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York NY, USA,Karolinska Inst, Stockholm, Sweden.;Örebro Univ Hosp, Örebro, Sweden.;Univ Nottingham, Sch Med, Nottingham, England.;Columbia Univ Coll Phys & Surg, Celiac Dis Ctr, 630 W 168th St, New York, NY 10032 USA.
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- Winell, Henric (författare)
- Karolinska Institutet,Uppsala universitet,Statistiska institutionen,Karolinska Inst, Stockholm, Sweden.
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- Sandin, Sven (författare)
- Karolinska Institutet
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- Cnattingius, Sven (författare)
- Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Stockholm, Sweden.;Seaver Autism Ctr Res Treatment Mt Sinai, New York, NY USA.
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- Stephansson, Olof (författare)
- Karolinska Institutet
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- Pasternak, Bjorn (författare)
- Karolinska Institutet
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(creator_code:org_t)
- American College of Physicians, 2020
- 2020
- Engelska.
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Ingår i: Annals of Internal Medicine. - : American College of Physicians. - 0003-4819 .- 1539-3704. ; 173:8, s. 597-604
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.7...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- Background: There are concerns that influenza vaccine exposure during pregnancy may be associated with increased risk for autism spectrum disorder (ASD).Objective: To examine the risk for ASD in offspring of mothers who were vaccinated against influenza A(H1N1)pdm09 ("swine flu") during pregnancy.Design: Population-based cohort study using nationwide registers.Setting: Seven health care regions in Sweden.Participants: Live births between October 2009 and September 2010, with follow-up through December 2016. In total, 39 726 infants were prenatally exposed to H1N1 vaccine (13 845 during the first trimester) and 29 293 infants were unexposed.Measurements: Cox regression was used to estimate hazard ratios (HRs) for the primary outcome, ASD, before and after adjustment for potential confounders. The secondary outcome was autistic disorder (AD).Results: Mean follow up was 6.7 years in both unexposed and exposed children. During follow-up, 394 (1.0%) vaccine-exposed and 330 (1.1%) unexposed children had a diagnosis of ASD. In adjusted analyses, prenatal exposure to H1N1 vaccination was not associated with a later diagnosis of ASD (adjusted HR [aHR], 0.95 [95% CI, 0.81 to 1.12]) or AD (aHR, 0.96 [CI, 0.80 to 1.16]). The 6-year standardized cumulative incidence difference between the unexposed and exposed children was 0.04% (CI, -0.09% to 0.17%) for ASD and 0.02% (CI, -0.09% to 0.14%) for AD. Restricting the analysis to vaccination in the first trimester of pregnancy did not influence risk estimates (aHR, 0.92 [CI, 0.74 to 1.16] for ASD and 0.91 [Cl, 0.70 to 1.18] for AD).Limitation: Data on H1N1 influenza infection are lacking.Conclusion: This large cohort study found no association between maternal H1N1 vaccination during pregnancy and risk for ASD in the offspring. Primary Funding Source: Swedish Research Council.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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