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Genomic analysis of the meningococcal ST-4821 complex-Western clade, potential sexual transmission and predicted antibiotic susceptibility and vaccine coverage

Lucidarme, Jay (författare)
Meningococcal Reference Unit, Public Health England, Manchester Royal Infirmary, Manchester, United Kingdom
Zhu, Bingqing (författare)
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China
Xu, Li (författare)
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China
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Bai, Xilian (författare)
Meningococcal Reference Unit, Public Health England, Manchester Royal Infirmary, Manchester, United Kingdom
Gao, Yuan (författare)
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China
González-López, Juan José (författare)
Department of Clinical Microbiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Mulhall, Robert (författare)
Irish Meningitis and Sepsis Reference Laboratory, Children's Health Ireland at Temple Street, Dublin, Ireland
Scott, Kevin J. (författare)
Bacterial Respiratory Infection Service, Scottish Microbiology Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom
Smith, Andrew (författare)
Bacterial Respiratory Infection Service, Scottish Microbiology Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom; College of Medical, Veterinary & Life Sciences, Glasgow Dental Hospital & School, University of Glasgow, Glasgow, United Kingdom
Stefanelli, Paola (författare)
Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy
Stenmark, Bianca, 1987- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine
Torpiano, Paul (författare)
Department of Child and Adolescent Health, Mater Dei Hospital, Msida, Malta
Tzanakaki, Georgina (författare)
National Meningitis Reference Laboratory, Dept. of Public Health Policy, School of Public Health, University of West Attica, Athens, Greece
Borrow, Ray (författare)
Meningococcal Reference Unit, Public Health England, Manchester Royal Infirmary, Manchester, United Kingdom
Shao, Zhujun (författare)
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China
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 (creator_code:org_t)
2020-12-10
2020
Engelska.
Ingår i: PLOS ONE. - : PLOS. - 1932-6203. ; 15:12
Relaterad länk:
https://doi.org/10.1...
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https://journals.plo...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • INTRODUCTION: The ST-4821 complex (cc4821) is a leading cause of serogroup C and serogroup B invasive meningococcal disease in China where diverse strains in two phylogenetic groups (groups 1 and 2) have acquired fluoroquinolone resistance. cc4821 was recently prevalent among carriage isolates in men who have sex with men in New York City (USA). Genome-level population studies have thus far been limited to Chinese isolates. The aim of the present study was to build upon these with an extended panel of international cc4821 isolates.METHODS: Genomes of isolates from Asia (1972 to 2017), Europe (2011 to 2018), North America (2007), and South America (2014) were sequenced or obtained from the PubMLST Neisseria database. Core genome comparisons were performed in PubMLST.RESULTS: Four lineages were identified. Western isolates formed a distinct, mainly serogroup B sublineage with alleles associated with fluoroquinolone susceptibility (MIC <0.03 mg/L) and reduced penicillin susceptibility (MIC 0.094 to 1 mg/L). A third of these were from anogenital sites in men who have sex with men and had unique denitrification gene alleles. Generally 4CMenB vaccine strain coverage was reliant on strain-specific NHBA peptides.DISCUSSION: The previously identified cc4821 group 2 was resolved into three separate lineages. Clustering of western isolates was surprising given the overall diversity of cc4821. Possible association of this cluster with the anogenital niche is worthy of monitoring given concerns surrounding antibiotic resistance and potential subcapsular vaccine escape.

Ämnesord

NATURVETENSKAP  -- Biologi -- Mikrobiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Microbiology (hsv//eng)

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