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Laparoscopic extend...
Laparoscopic extended pelvic lymph node (LN) dissection as validation of the performance of [(11) C]-acetate positron emission tomography/computer tomography in the detection of LN metastasis in intermediate- and high-risk prostate cancer
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- Daouacher, Georgios, 1978- (författare)
- Department of Urology, Central Hospital of Karlstad, Karlstad, Sweden
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- von Below, Catrin (författare)
- Uppsala universitet,Radiologi
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- Gestblom, Charlotta (författare)
- Department of Pathology, Central Hospital of Karlstad, Karlstad, Sweden
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- Ahlström, Håkan (författare)
- Uppsala universitet,Radiologi
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- Grzegorek, Rafael (författare)
- Department of Urology, Central Hospital of Karlstad, Karlstad, Sweden
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- Wassberg, Cecilia (författare)
- Uppsala universitet,Radiologi
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- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi
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- Waldén, Mauritz (författare)
- Department of Urology, Central Hospital of Karlstad, Karlstad, SwedenDepartment of Urology, Central Hospital of Karlstad, Karlstad, Sweden
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(creator_code:org_t)
- 2015-07-20
- 2016
- Engelska.
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Ingår i: BJU International. - : Blackwell Publishing. - 1464-4096 .- 1464-410X. ; 118:1, s. 77-83
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: To evaluate the accuracy of the radiopharmaceutical [(11) C]-acetate combined with positron emission tomography/computer tomography (acetate-PET/CT) in lymph node (LN) staging in newly diagnosed prostate cancer cases. A second aim was to evaluate the potential discriminative properties of acetate-PET/CT in clinical routine.PATIENTS AND METHODS: In a prospective comparative study, from July 2010 to June 2013, 53 men with newly histologically diagnosed intermediate- or high-risk prostate cancer underwent acetate-PET/CT investigation at one regional centre before laparoscopic extended pelvic LN dissection (ePLND) at one referral centre. The sensitivity, specificity and accuracy of acetate-PET/CT were calculated. Comparisons were made between true-positive and false-negative PET/CT cases to identify differences in the clinical parameters: PSA level, Gleason status, lymph metastasis burden and size, calculated risk of LN involvement, and curative treatment decisions.RESULTS: In all, 26 patients had surgically/histologically confirmed LN metastasis (LN+). Acetate-PET/CT was true positive in 10 patients, false positive in one, false negative in 16, and true negative in 26. The individual sensitivity was 38%, specificity 96%, and accuracy 68%. The acetate-PET/CT positive cases had significantly more involved LNs (mean 7.9 vs 2.4, P < 0.001) with larger cancer diameters (14.1 vs 4.9 mm, P = 0.001) and fewer eventually had treatment with curative intent (40% vs 94%, P <0.005), although we lack long-term outcome data.CONCLUSION: Acetate-PET/CT has too low a sensitivity for routine LN staging but the specificity is high. The acetate-PET/CT positive cases have a very high burden of LN spread.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Laparoscopy
- lymph node staging
- lymph nodes
- position emission tomography
- prostate cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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