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Epidural Analgesia ...
Epidural Analgesia for Colorectal Cancer Surgery : Experimental and Clinical studies
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- Falk, Wiebke, 1978- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Gupta, Anil, docent, 1957- (preses)
- Karolinska institutet
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- Matthiessen, Peter, professor, 1957- (preses)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Hjelmqvist, Hans, professor, 1958- (preses)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Åkeson, Jonas, professor (opponent)
- Lunds universitet
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(creator_code:org_t)
- ISBN 9789175293844
- Örebro : Örebro University, 2021
- Engelska 67 s.
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Serie: Örebro Studies in Medicine, 1652-4063 ; 237
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Abstract
Ämnesord
Stäng
- Epidural analgesia (EA) with local anaesthetics and opioids is used for pain management after colorectal cancer (CRC) surgery. In recent years, a possible beneficial effect of EA on cancer recurrence and survival after surgery has been proposed. The aim of this thesis was to study the effects of EA on short- and long-term postoperative outcomes after CRC surgery with curative intent.Study I, an in vitro study, investigated the effects of two different local anaesthetics, lidocaine and ropivacaine, on cell viability and cell proliferation in colon cancer cell lines SW480 and SW620. Neither lidocaine nor ropivacaine reduced cell viability or proliferation at systemically, by epidural administration achievable concentrations.In study II, the effect of EA on the systemic level of different cytokines as a marker of inflammation was studied. Except for a reduced level of the anti-inflammatory cytokine IL-10, no other significant effects of EA on the systemic cytokine levels at two time points postoperatively could be shown, when compared to patients receiving intravenous morphine.Study III was an epidemiological study, examining the question if EA affects postoperative complications and mortality after surgery using data from the Swedish Colorectal Cancer Registry and the Swedish Perioperative Registry. No association between EA and a reduction in postoperative complications or mortality could be established.Study IV, a randomised, controlled trial, the effects of EA on diseasefree survival (DFS), postoperative complications and pain after surgery were compared to patient-controlled intravenous analgesia with morphine. Apart from superior pain relief during the first postoperative day, no significant effects of EA on the occurrence of postoperative complications, length of hospital stay or DFS were found.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- colorectal cancer
- epidural analgesia
- local anaesthetics
- colon cancer cells
- inflammation
- postoperative complications
- pain
- recurrence
- disease-free survival
- mortality
Publikations- och innehållstyp
- vet (ämneskategori)
- dok (ämneskategori)
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