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Vasculoprotective P...
Vasculoprotective Properties of Plasma Lipoproteins from Brown Bears (Ursus arctos)
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- Pedrelli, Matteo (författare)
- Karolinska Institutet
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- Parini, Paolo (författare)
- Karolinska Institutet
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- Kindberg, Jonas (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Norwegian Institute for Nature Research (NINA)
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- Arnemo, Jon (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Inland Norway University of Applied Sciences
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- Bjorkhem, Ingemar (författare)
- Karolinska Institutet
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- Aasa, Ulrika (författare)
- Department of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden
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- Westerståhl, Maria (författare)
- Karolinska Institutet
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- Walentinsson, Anna (författare)
- Translational Science & Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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- Pavanello, Chiara (författare)
- Centro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy
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- Turri, Marta (författare)
- Centro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy
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- Calabresi, Laura (författare)
- Centro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy
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- Öörni, Katariina (författare)
- Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland
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- Camejo, Gérman (författare)
- Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
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- Fröbert, Ole, 1964- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Swedish University of Agricultural Sciences, Department of Wildlife, Fish, and Environmental Studies, Umeå, Sweden; Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden
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- Hurt-Camejo, Eva (författare)
- Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Translational Science & Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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(creator_code:org_t)
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- American Society for Biochemistry and Molecular Biology, 2021
- 2021
- Engelska.
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Ingår i: Journal of Lipid Research. - : American Society for Biochemistry and Molecular Biology. - 0022-2275 .- 1539-7262. ; 62
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Abstract
Ämnesord
Stäng
- Plasma cholesterol and triglyceride levels are twice as high in hibernating brown bears (Ursus arctos) than healthy humans. Yet, bears display no signs of early-stage atherosclerosis development when adult. To explore this apparent paradox, we analysed plasma lipoproteins from the same ten bears in winter (hibernation) and in summer using size exclusion chromatography, ultracentrifugation and electrophoresis. LDL cholesterol binding to arterial proteoglycans, and plasma cholesterol efflux capacity were also evaluated. The data collected and analysed from bears were also compared with those from healthy humans. In bears the cholesterol esters, unesterified cholesterol, triglyceride and phospholipid content of VLDL and LDL were higher in winter than in summer. The percentage lipid composition of LDL differed between bears and humans, but did not change seasonally in bears. Bear LDL was larger, richer in triglycerides, showed pre-beta electrophoretic mobility and had 5-10 times lower binding to arterial proteoglycans than human LDL. Finally, plasma cholesterol efflux capacity was higher in bears than in humans, especially the HDL fraction when mediated by ABCA1. These results suggest that in brown bears the absence of early atherogenesis is likely associated with a lower affinity of LDL cholesterol for arterial proteoglycans and an elevated cholesterol efflux capacity of bear plasma.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Clinical Science (hsv//eng)
Nyckelord
- LDL
- Ursus arctos
- apoB
- atherosclerosis
- cholesterol efflux
- hibernation
- lipids
- lipoproteins
- proteoglycans
- triglycerides
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pedrelli, Matteo
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Parini, Paolo
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Kindberg, Jonas
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Arnemo, Jon
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Bjorkhem, Ingema ...
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Aasa, Ulrika
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Westerståhl, Mar ...
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Walentinsson, An ...
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Pavanello, Chiar ...
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Turri, Marta
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Calabresi, Laura
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Öörni, Katariina
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Camejo, Gérman
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Fröbert, Ole, 19 ...
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Hurt-Camejo, Eva
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Veterinärmedicin
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och Klinisk vetenska ...
- Artiklar i publikationen
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Journal of Lipid ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Sveriges Lantbruksuniversitet