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Gold nanoparticles ...
Gold nanoparticles coated with polyvinylpyrrolidone and sea urchin extracellular molecules induce transient immune activation
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- Alijagic, Andi, 1992- (författare)
- Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Palermo, Italy
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- Barbero, Francesco (författare)
- Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, Barcelona, Spain
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- Gaglio, Daniela (författare)
- Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), Segrate, MI, Italy; SYSBIO.IT, Centre of Systems Biology, University of Milano-Bicocca, Milano, Italy
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- Napodano, Elisabetta (författare)
- SYSBIO.IT, Centre of Systems Biology, University of Milano-Bicocca, Milano, Italy
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- Benada, Oldřich (författare)
- Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
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- Kofroňová, Olga (författare)
- Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
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- Puntes, Victor F (författare)
- Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; Vall d Hebron, Institut de Recerca (VHIR), Barcelona, Spain
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- Bastús, Neus G (författare)
- Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, Barcelona, Spain
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- Pinsino, Annalisa (författare)
- Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Palermo, Italy
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(creator_code:org_t)
- Amsterdam : Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Journal of Hazardous Materials. - Amsterdam : Elsevier. - 0304-3894 .- 1873-3336. ; 402
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We report that the immunogenicity of colloidal gold nanoparticles coated with polyvinylpyrrolidone (PVP-AuNPs) in a model organism, the sea urchin Paracentrotus lividus, can function as a proxy for humans for in vitro immunological studies. To profile the immune recognition and interaction from exposure to PVP-AuNPs (1 and 10 μg mL-1), we applied an extensive nano-scale approach, including particle physicochemical characterisation involving immunology, cellular biology, and metabolomics. The interaction between PVP-AuNPs and soluble proteins of the sea urchin physiological coelomic fluid (blood equivalent) results in the formation of a protein "corona" surrounding the NPs from three major proteins that influence the hydrodynamic size and colloidal stability of the particle. At the lower concentration of PVP-AuNPs, the P. lividus phagocytes show a broad metabolic plasticity based on the biosynthesis of metabolites mediating inflammation and phagocytosis. At the higher concentration of PVP-AuNPs, phagocytes activate an immunological response involving Toll-like receptor 4 (TLR4) signalling pathway at 24 hours of exposure. These results emphasise that exposure to PVP-AuNPs drives inflammatory signalling by the phagocytes and the resolution at both the low and high concentrations of the PVP-AuNPs and provides more details regarding the immunogenicity of these NPs.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Immune metabolic rewiring
- Immunoreactivity
- Innate defence response
- Nano-recognition
- Sea urchin immune cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Alijagic, Andi, ...
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Barbero, Frances ...
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Gaglio, Daniela
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Napodano, Elisab ...
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Benada, Oldřich
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Kofroňová, Olga
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visa fler...
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Puntes, Victor F
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Bastús, Neus G
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Pinsino, Annalis ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Fysikalisk kemi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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och Miljövetenskap
- Artiklar i publikationen
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Journal of Hazar ...
- Av lärosätet
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Örebro universitet