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Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction : Rationale and design of the EURO-ICE trial

El Farissi, Mohamed (author)
Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
Keulards, Danielle C. J. (author)
Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
van 't Veer, Marcel (author)
Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
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Zelis, Jo M. (author)
Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
Berry, Colin (author)
Department of Cardiology, Golden Jubilee National Hospital, Glasgow, United Kingdom
De Bruyne, Bernard (author)
Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium
Engstrøm, Thomas (author)
Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
Fröbert, Ole, 1964- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology
Piroth, Zsolth (author)
Department of Adult Cardiology, Hungarian Institute of Cardiology, Budapest, Hungary
Oldroyd, Keith G. (author)
Department of Cardiology, Golden Jubilee National Hospital, Glasgow, United Kingdom
Tonino, Pim A. L. (author)
Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
Pijls, Nico H. J. (author)
Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
Otterspoor, Luuk C. (author)
Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
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 (creator_code:org_t)
European Society of Cardiology, 2021
2021
English.
In: EuroIntervention. - : European Society of Cardiology. - 1774-024X .- 1969-6213. ; 16:17, s. 1444-1446
Related links:
https://urn.kb.se/re...
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https://doi.org/10.4...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect.Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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ref (subject category)
art (subject category)

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