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A common model for ...
A common model for the breathlessness experience across cardiorespiratory disease
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- Finnegan, Sarah L. (author)
- Wellcome Centre for Integrative Neuroimaging and Nuffield Division of Anaesthetics, Nuffield Dept of Clinical Neurosciences, University of Oxford, Oxford, UK,Univ Oxford, Wellcome Ctr Integrat Neuroimaging & Nuffield Div, Nuffield Dept Clin Neurosci, Oxford, England.
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- Pattinson, Kyle T. S. (author)
- Wellcome Centre for Integrative Neuroimaging and Nuffield Division of Anaesthetics, Nuffield Dept of Clinical Neurosciences, University of Oxford, Oxford, UK,Univ Oxford, Wellcome Ctr Integrat Neuroimaging & Nuffield Div, Nuffield Dept Clin Neurosci, Oxford, England.
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- Sundh, Josefin, 1972- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Respiratory Medicine,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Dept Resp Med, Örebro, Sweden.
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- Sköld, Magnus (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Resp Med Unit, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Resp Med & Allergy, Stockholm, Sweden.
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- Janson, Christer (author)
- Uppsala universitet,Uppsala University,Lung- allergi- och sömnforskning
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- Blomberg, Anders, 1961- (author)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, Sect Med, Umeå, Sweden.
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- Sandberg, Jacob (author)
- Lund University,Lunds universitet,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Breathlessness and chronic respiratory failure,Lund University Research Groups,Lund Univ, Fac Med, Dept Clin Sci, Resp Med & Allergol, Lund, Sweden.
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- Ekström, Magnus (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Breathlessness and chronic respiratory failure,Lund University Research Groups,Lund Univ, Fac Med, Dept Clin Sci, Resp Med & Allergol, Lund, Sweden.
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Wellcome Centre for Integrative Neuroimaging and Nuffield Division of Anaesthetics, Nuffield Dept of Clinical Neurosciences, University of Oxford, Oxford, UK Univ Oxford, Wellcome Ctr Integrat Neuroimaging & Nuffield Div, Nuffield Dept Clin Neurosci, Oxford, England (creator_code:org_t)
- 2021-03-11
- 2021
- English.
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In: ERJ Open Research. - Sheffield : European Respiratory Society. - 2312-0541. ; 7:2
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Abstract
Subject headings
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- Chronic breathlessness occurs across many different conditions, often independently of disease severity. Yet, despite being strongly linked to adverse outcomes, the consideration of chronic breathlessness as a stand-alone therapeutic target remains limited. Here we use data-driven techniques to identify and confirm the stability of underlying features (factors) driving breathlessness across different cardiorespiratory diseases.Questionnaire data on 182 participants with main diagnoses of asthma (21.4%), COPD (24.7%), heart failure (19.2%), idiopathic pulmonary fibrosis (18.7%), other interstitial lung disease (2.7%), and "other diagnoses" (13.2%) were entered into an exploratory factor analysis (EFA). Participants were stratified based on their EFA factor scores. We then examined model stability using 6-month follow-up data and established the most compact set of measures describing the breathlessness experience.In this dataset, we have identified four stable factors that underlie the experience of breathlessness. These factors were assigned the following descriptive labels: 1) body burden, 2) affect/mood, 3) breathing burden and 4) anger/frustration. Stratifying patients by their scores across the four factors revealed two groups corresponding to high and low burden. These two groups were not related to the primary disease diagnosis and remained stable after 6 months.In this work, we identified and confirmed the stability of underlying features of breathlessness. Previous work in this domain has been largely limited to single-diagnosis patient groups without subsequent re-testing of model stability. This work provides further evidence supporting disease independent approaches to assess breathlessness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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