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The Role of Electro...
The Role of Electrochemotherapy in Curative Treatment of Head and Neck Cancer and Advanced Skin Cancer : A Need for New Treatment Protocols?
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- Landström, Fredrik, 1966- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden
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- Kristiansson, Stefan (författare)
- Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden
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- Reizenstein, Johan (författare)
- Department of Oncology, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2021-07-19
- 2021
- Engelska.
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Ingår i: Anticancer Research. - : International Institute of Anticancer Research. - 0250-7005 .- 1791-7530. ; 41:8, s. 3977-3982
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- BACKGROUND/AIM: Electrochemotherapy (ECT) is a cancer treatment modality where the efficacy of a chemotherapeutic agent is enhanced by an electrical field. It is an established palliative treatment for cutaneous metastases but its role in curative treatment remains mostly undetermined. Studies have previously reported that ECT can be a safe curative treatment in both skin cancer and oral cavity cancer. The primary aim of this case study was to report the long-term results of ECT in curative treatment of four patients with skin or oral cavity cancer. The study also compares two different ECT treatment protocols.PATIENTS AND METHODS: Three patients with oral cavity cancer and one patient with skin cancer were included. One patient had a primary oral tongue cancer and the others had persistent/recurrent tumors after previous treatment. They were treated with ECT either as a primary, adjuvant or salvage treatment with curative intent. The median follow-up period was 60 months.RESULTS: There was one case of local recurrence after treatment in the follow-up period. In the other three patients, no recurrence was recorded. There was one serious adverse airway event. There was a significant difference in the bleomycin dose between the two studied protocols, especially for large tumors.CONCLUSION: ECT can be a safe mono-modality and adjuvant curative treatment in advanced skin cancer and primary and recurrent oral cavity cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Electrochemotherapy
- curative treatment
- head and neck cancer
- skin cancer
- squamous cell carcinoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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