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Sökning: id:"swepub:oai:DiVA.org:oru-93535" > Skeletal adverse ev...

Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study

Oskarsson, Trausti (författare)
Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
Duun-Henriksen, Anne Katrine (författare)
Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark,Danish Canc Soc Res Ctr, Childhood Canc Res Grp, Copenhagen, Denmark.
Bautz, Andrea (författare)
Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark,Danish Canc Soc Res Ctr, Childhood Canc Res Grp, Copenhagen, Denmark.
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Montgomery, Scott, 1961- (författare)
Karolinska Institutet,Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology Division, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK,Clinical Epidemiology and Biostatistics,Örebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Örebro, Sweden.;Karolinska Univ Hosp, Karolinska Inst, Div Clin Epidemiol, Stockholm, Sweden.;UCL, Dept Epidemiol & Publ Hlth, London, England.
Harila-Saari, Arja H. (författare)
Uppsala University,Karolinska Institute,Uppsala universitet,Barnneurologi/Barnonkologi,Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden.,Aarhus Univ Hosp, Dept Paediat, Aarhus, Denmark.,Aarhus University Hospital
Petersen, Cecilia (författare)
Karolinska Institutet
Niinimäki, Riitta (författare)
Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland,Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland.
Madanat-Harjuoja, Laura (författare)
Finnish Institute for Statistical and Epidemiological Cancer Research, Finnish Cancer Registry, Helsinki, Finland; Dana-Farber Cancer Institute/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA; Department of Pediatrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland,Finnish Canc Registry, Finnish Inst Stat & Epidemiol Canc Res, Helsinki, Finland.;Harvard Med Sch, Boston Childrens Canc & Blood Disorders Ctr, Dana Farber Canc Inst, Boston, MA 02115 USA.;Univ Helsinki, Dept Pediat, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
Tryggvadóttir, Laufey (författare)
The Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland,Iceland Canc Soc, Iceland Canc Registry, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
Holmqvist, Anna Sällfors (författare)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
Hasle, Henrik (författare)
Department of Paediatrics, Aarhus University Hospital, Aarhus, Denmark
Heyman, Mats (författare)
Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
Winther, Jeanette Falck (författare)
Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University and University Hospital, Aarhus, Denmark,Danish Canc Soc Res Ctr, Childhood Canc Res Grp, Copenhagen, Denmark.;Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus, Denmark.;Univ Hosp, Aarhus, Denmark.
ALiCCS study group, - (bidragsgivare)
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 (creator_code:org_t)
2021-07-30
2021
Engelska.
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 149:11, s. 1863-1876
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age- and sex-matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first-time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29-1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0-44.5), osteoporosis, RR 4.53 (3.28-6.27), fractures, RR 1.27 (1.20-1.34), osteochondropathies, RR 1.57 (1.28-1.92) and osteoarthrosis, RR 1.48 (1.28-1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high-risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

ALiCCS
childhood cancer
late effects
skeletal adverse events
survivorship
ALiCCS
childhood cancer
late effects
skeletal adverse events
survivorship

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