Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease: A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort

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Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease : A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort

Vatn, Simen Svendsen (författare): Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

Lindstrøm, Jonas Christoffer (författare): Health Services Research Unit (HØKH), Akershus University Hospital, Lørenskog, Norway; Department of Methods Development and Analytics, Division of Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway,Akershus Univ Hosp, Norway; Norwegian Inst Publ Hlth, Norway

Moen, Aina E. F. (författare): Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Methods Development and Analytics, Division of Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway; Section for Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Norwegian Inst Publ Hlth, Norway; Akershus Univ Hosp, Norway

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Brackmann, Stephan (författare): Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

Tannæs, Tone M. (författare): Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section for Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

Olbjørn, Christine (författare): Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

Bergemalm, Daniel, 1977- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology,Orebro Univ, Sweden

Keita, Åsa (författare): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten

Gomollon, Fernando (författare): Digestive Diseases Unit, IIS Aragón, Zaragoza, Spain

Detlie, Trond Espen (författare): Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

Lüders, Torben (författare): Section for Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway

Kalla, Rahul (författare): Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK,Univ Edinburgh, Scotland

Adams, Alex (författare): Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK; Translational Gastroenterology Unit, Medical Sciences/ Experimental medicine Division, University of Oxford, Oxford, UK,Univ Edinburgh, Scotland; Univ Oxford, England

Satsangi, Jack (författare): Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK; Translational Gastroenterology Unit, Medical Sciences/ Experimental medicine Division, University of Oxford, Oxford, UK,Univ Edinburgh, Scotland; Univ Oxford, England

Jahnsen, Jørgen (författare): Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

Vatn, Morten H. (författare): Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Univ Oslo, Norway

Halfvarson, Jonas, 1970- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Orebro Univ, Sweden

Ricanek, Petr (författare): Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway

Nilsen, Hilde (författare): Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section for Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

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Dove Medical Press Ltd. 2022
2022
Engelska.
Ingår i: Clinical and Experimental Gastroenterology. - : Dove Medical Press Ltd.. - 1178-7023. ; 15, s. 5-25

Relaterad länk:: https://doi.org/10.2...; visa fler...; https://liu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.2...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: Studies of the mucosal transcriptomic landscape have given new insight into the pathogenesis of inflammatory bowel disease (IBD). Recently, the predictive biomarker potential of gene expression signatures has been explored. To further investigate the mucosal gene expression in IBD, we recruited a cohort of treatment naïve patients and compared them to both symptomatic and healthy controls.Methods: Altogether, 323 subjects were included: Crohn's disease (N = 75), ulcerative colitis (N = 87) and IBD unclassified (N = 3). Additionally, there were two control groups: symptomatic controls (N = 131) and healthy controls (N = 27). Mucosal biopsies were collected during ileocolonoscopy and gene expression in inflamed and non-inflamed mucosa was explored. Gene expression profiling was performed using Agilent G3 Human Gene Expression 860K v3 One-Color microarray. We recorded information about treatment escalation to anti-TNF agents or surgery, and anti-TNF response, to explore predictive opportunities of the mucosal transcriptome.Results: Gene expression profiles in symptomatic controls in whom IBD had been excluded resembled that of IBD patients and diverged from that of healthy controls. In non-inflamed Crohn's disease and ulcerative colitis, gene set enrichment analysis revealed dysregulation of pathways involved in basic cellular biological processes. Mitochondria-associated pathways were dysregulated both in non-inflamed and inflamed Crohn's disease and ulcerative colitis (>2.6 normalized enrichment scores <-1.8). Gene expression signatures of Crohn's disease and ulcerative colitis did not predict time for treatment escalation (p = 0.175). No significant association was found between gene expression signatures and anti-TNF response.Conclusion: Non-inflamed samples are probably superior to inflamed samples when exploring gene expression signatures in IBD and might reveal underlying mechanisms central for disease initiation. The gene expression signatures of the control groups were related to if they were symptomatic or not, which may have important implications for future study designs.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

Crohn’s disease
healthy controls
mitochondria
mucosal transcriptome
non-inflamed
prediction
symptomatic controls
ulcerative colitis

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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Av lärosätet: Örebro universitet; Linköpings universitet

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