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Work loss before an...
Work loss before and after diagnosis in patients with celiac disease
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- Bozorg, Soran Rabin, 1993- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm Sweden
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- Söderling, Jonas (författare)
- Clinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Sweden
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- Everhiv, Åsa H. (författare)
- Clinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Sweden; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
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- Lebwohl, Benjamin (författare)
- Celiac Disease Center, Department of Medicine, Columbia University Medical Centre, Columbia University, New York, USA
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- Green, Peter H. R. (författare)
- Celiac Disease Center, Department of Medicine, Columbia University Medical Centre, Columbia University, New York, USA
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- Neovius, Martin (författare)
- Clinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Sweden
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- Ludvigsson, Jonas F., 1969- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm Sweden; Celiac Disease Center, Department of Medicine, Columbia University Medical Centre, Columbia University, New York, USA; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden
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- Mårild, Karl (författare)
- Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden; Department of Pediatric Gastroenterology, Queen Silvia Children’s Hospital, Gothenburg, Sweden
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(creator_code:org_t)
- John Wiley & Sons, 2021
- 2021
- Engelska.
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Ingår i: European Journal of Immunology. - : John Wiley & Sons. - 0014-2980 .- 1521-4141. ; 51:Suppl. 1, s. 286-286
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Celiac disease (CD) is an immune‐mediated disease triggered by gluten intake and affects around 1% of the population worldwide. Although patients with CD have an increased use of healthcare, data on work disability remains scarce. To estimate work loss in patients with CD before and after diagnosis. We identified 16,005 working‐age patients with prevalent CD, and 4,936 incident working‐age patients diagnosed in 2008‐2015 through biopsy reports from Sweden’s 28 pathology departments. CD was defined by presence of villus atrophy (Marsh 3) on biopsy (gold standard). Each patient was compared to up to 5 matched general‐population comparators. Using nationwide social insurance registers, we retrieved prospectively‐recorded data on compensation for sick leave and disability. In 2015, patients with prevalent CD had a mean of 42.5 (95%CI: 40.9‐44.1) lost work days as compared with 28.6 (27.9‐29.2) in the general‐population comparators, corresponding to a relative difference of 49%. Among incident patients, the annual mean difference between patients and comparators was 8.0 (5.4‐10.6) lost work days 5 years before CD diagnosis, which grew to 13.7 (9.1‐18.3) days 5 years after diagnosis. In addition to the continuously increasing mean difference in lost work days over time, there was also a transient increase in work loss in patients with CD during the year of diagnosis (mean difference: 15.6 days, 95%CI: 13.1‐18.0). Patients with CD miss more work days than comparators before their diagnosis, and this loss increases and persists after diagnosis despite presumed installation of treatment with gluten‐free diet.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Autoimmunity
- inflammatory disease
- inflammatory bowel disease
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