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Impact of remission...
Impact of remission and low disease activity on health-related quality of life in patients with systemic lupus erythematosus
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- Emamikia, Sharzad (författare)
- Karolinska Institutet
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- Oon, Shereen (författare)
- Departments of Medicine and Rheumatology, The University of Melbourne at St Vincent's Hospital, Fitzroy, Victoria, Australia
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- Gomez, Alvaro (författare)
- Karolinska Institutet
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- Lindblom, Julius (författare)
- Karolinska Institutet
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- Borg, Alexander (författare)
- Karolinska Institutet
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- Enman, Yvonne (författare)
- Karolinska Institutet
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- Morand, Eric (författare)
- School of Clinical Sciences at Monash Health, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre Clayton, Clayton, Victoria, Australia
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- Grannas, David (författare)
- Divison of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- van Vollenhoven, Ronald F. (författare)
- Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Amsterdam, The Netherlands
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- Nikpour, Mandana (författare)
- Departments of Medicine and Rheumatology, The University of Melbourne at St Vincent's Hospital, Fitzroy, Victoria, Australia
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- Parodis, Ioannis, 1981- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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(creator_code:org_t)
- 2022-03-18
- 2022
- Engelska.
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Ingår i: Rheumatology. - : Oxford University Press. - 1462-0324 .- 1462-0332. ; 61:12, s. 4752-4762
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: To investigate the impact of remission and lupus low disease activity state (LLDAS) on health-related quality of life (HRQoL) in systemic lupus erythematosus.METHODS: SF-36, EQ-5D-3L and FACIT-Fatigue data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials were used. Duration in remission/LLDAS required to reach a HRQoL benefit ≥ minimal clinically important differences (MCIDs) during and post-treatment was determined using quantile regression and generalised estimating equations.RESULTS: Patients (N = 1684) were assessed every 4th week (15 visits). Four cumulative (β = 0.60) or four consecutive (β = 0.66) visits in remission were required to achieve a benefit ≥MCID in SF-36 physical component summary (PCS) scores, and six cumulative (β = 0.44) or five consecutive (β = 0.49) for a benefit ≥MCID in mental component summary (MCS) scores. Eight cumulative (β = 0.30 for both) or eight consecutive (β = 0.32 for both) visits in LLDAS were required for a benefit in PCS/MCS ≥MCID, respectively.For EQ-5D-3L index scores ≥MCID, six cumulative (β = 0.007) or five consecutive (β = 0.008) visits in remission were required, and eight cumulative (β = 0.005) or six consecutive (β = 0.006) visits in LLDAS. For FACIT-Fatigue scores ≥MCID, 12 cumulative (β = 0.34) or 10 consecutive (β = 0.39) visits in remission were required, and 17 cumulative (β = 0.24) or 16 consecutive (β = 0.25) visits in LLDAS.CONCLUSION: Remission and LLDAS contribute to a HRQoL benefit in a time-dependent manner. Shorter time in remission than in LLDAS was required for a clinically important benefit in HRQoL, and longer time in remission for a benefit in mental compared with physical HRQoL aspects. When remission/LLDAS was sustained, the same benefit was achieved in a shorter time.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- health-related quality of life
- lupus low disease activity state
- remission
- systemic lupus erythematosus
- treat-to-target
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Emamikia, Sharza ...
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Oon, Shereen
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Gomez, Alvaro
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Lindblom, Julius
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Borg, Alexander
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Enman, Yvonne
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Morand, Eric
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Grannas, David
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van Vollenhoven, ...
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Nikpour, Mandana
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Parodis, Ioannis ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Rheumatology
- Av lärosätet
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Örebro universitet
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Karolinska Institutet