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Examination of aryl...
Examination of aryl hydrocarbon receptor (AhR), estrogenic and anti-androgenic activities, and levels of polyaromatic compounds (PACs) in tire granulates using in vitro bioassays and chemical analysis
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- Eriksson, Ulrika, 1972- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment (MTM
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- Titaley, Ivan A. (författare)
- School of Science and Technology, Örebro University, Örebro, Sweden; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States,Man-Technology-Environment (MTM) Research Centre
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- Engwall, Magnus, 1965- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment (MTM)
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- Larsson, Maria, 1975- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment (MTM)
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(creator_code:org_t)
- Pergamon Press, 2022
- 2022
- Engelska.
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Ingår i: Chemosphere. - : Pergamon Press. - 0045-6535 .- 1879-1298. ; 298
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Tire granulates recovered from end-of-life tires contain a complex mixture of chemicals, amongst them polyaromatic compounds (PACs), of which many are recognized to be toxic and persistent in the environment. Only a few of these PACs are regularly monitored. In this study a combined approach of chemical analysis and a battery of CALUX® in vitro bioassays was used to determine PAC concentrations and estrogenic, (anti)-androgenic and aryl hydrocarbon receptor (AhR) activities in tire granulates. Tire granulates from a recycling company was analyzed for PAHs, alkyl-PAHs, oxy-PAHs and heterocyclic PACs (NSO-PACs), in total 85 PACs. The concentrations of PACs were between 42 and 144 mg/kg, with major contribution from PAHs (74-88%) followed by alkyl-PAHs (6.6-20%) and NSO-PACs (1.8-7.0%). The sum of eight priority PAHs were between 2.3 and 8.6 mg/kg, contributing with 4.7-8.2% of ∑PACs. Bioassay analysis showed presence of AhR agonists, estrogen receptor (ERα) agonists, and androgen receptor (AR) antagonists in the tire granulate samples. Only 0.8-2.4% of AhR-mediated activities could be explained by the chemical analysis. Benzo[k+j]fluoranthenes, benzo[b]fluoranthene, indeno[1,2,3-cd]pyrene, 2-methylchrysene, and 3-methylchrysene were the major contributors to the AhR-mediated activities. The high contribution (98-99%) of unknown bioactive compounds to the bioassay effects in this study raises concerns and urges for further investigations of toxicants identification and source apportionment.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Alkyl-PAHs
- Bioassay
- Circular economy
- Polycyclic aromatic hydrocarbons (PAHs)
- Tire granulates
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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