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Peptide-Loaded Cubo...
Peptide-Loaded Cubosomes Functioning as an Antimicrobial Unit against Escherichia coli
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- Boge, Lukas (författare)
- RISE,Yta, process och formulering,Chalmers University of Technology, Sweden,Chalmers tekniska högskola,RISE Research Institutes of Sweden,RISE Res Inst Sweden, S-50115 Boras, Sweden;Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden
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- Browning, Kathryn (författare)
- University of Copenhagen, Denmark,Köpenhamns universitet,Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark
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- Nordström, Randi (författare)
- Uppsala universitet,Institutionen för farmaci
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- Campana, Mario (författare)
- Rutherford Appleton Laboratory, UK,STFC Rutherford Appleton Laboratory,Rutherford Appleton Lab, Didcot OX11 0DE, Oxon, England
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- Damgaard, Liv (författare)
- University of Copenhagen, Denmark,Köpenhamns universitet,Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark
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- Seth Caous, Josefin (författare)
- RISE,Kemi och material,Metodik för produktframtagning,RISE Research Institutes of Sweden,RISE Res Inst Sweden, S-50115 Boras, Sweden
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- Hellsing, Maja (författare)
- RISE,Yta, process och formulering,RISE Research Institutes of Sweden,RISE Res Inst Sweden, S-50115 Boras, Sweden
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- Ringstad, Lovisa (författare)
- RISE,Kemi och material,RISE Research Institutes of Sweden,RISE Res Inst Sweden, S-50115 Boras, Sweden
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- Andersson, Martin, 1974 (författare)
- Chalmers University of Technology, Sweden,Chalmers tekniska högskola,Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden
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(creator_code:org_t)
- 2019-05-23
- 2019
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society. - 1944-8244 .- 1944-8252. ; 11:24, s. 21314-21322
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://research.cha...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Dispersions of cubic liquid crystalline phases, also known as cubosomes, have shown great promise as delivery vehicles for a wide range of medicines. Due to their ordered structure, comprising alternating hydrophilic and hydrophobic domains, cubosomes possess unique delivery properties and compatibility with both water-soluble and -insoluble drugs. However, the drug delivery mechanism and cubosome interaction with human cells and bacteria are still poorly understood. Herein, we reveal how cubosomes loaded with the human cathelicidin antimicrobial peptide LL-37, a system with high bacteria-killing effect, interact with the bacterial membrane and provide new insights into the eradication mechanism. Combining the advanced experimental techniques neutron reflectivity and quartz crystal microbalance with dissipation monitoring, a mechanistic drug delivery model for LL-37-loaded cubosomes on bacterial mimicking bilayers was constructed. Moreover, the cubosome interaction with Escherichia coli was directly visualized using super-resolution laser scanning microscopy and cryogenic electron tomography. We could conclude that cubosomes loaded with LL-37 adsorbed and distorted bacterial membranes, providing evidence that the peptide-loaded cubosomes function as an antimicrobial unit.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- antimicrobial peptide
- bacteria
- cubosome
- LL-37
- membrane
- Controlled drug delivery
- Electric impedance tomography
- Escherichia coli
- Membranes
- Peptides
- Targeted drug delivery
- Cubosomes
- Experimental techniques
- Hydrophilic and hydrophobic
- Laser scanning microscopy
- Liquid-crystalline phasis
- Quartz crystal microbalance with dissipation monitoring
- Drug interactions
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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