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Human transgenerati...
Human transgenerational responses to early-life experience : potential impact on development, health and biomedical research
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- Pembrey, Marcus (författare)
- School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; UCL Institute of Child Health, London, United Kingdom
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- Saffery, Richard (författare)
- Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia
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- Bygren, Lars Olov, 1936- (författare)
- Umeå universitet,Karolinska Institutet,Institutionen för samhällsmedicin och rehabilitering,Department of Bioscience and Nutrition, Karolinska Institute, Stockholm, Sweden,Socialmedicin,Department of Biosciences and Rehabilitation, Karolinska Institutet, Huddinge, Sweden
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- Edvinsson, Sören, 1953- (bidragsgivare)
- Umeå universitet,Enheten för demografi och åldrandeforskning (CEDAR)
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- Franks, Paul W. (bidragsgivare)
- Umeå universitet,Avdelningen för medicin,Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
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(creator_code:org_t)
- 2014-07-25
- 2014
- Engelska.
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Ingår i: Journal of Medical Genetics. - : BMJ. - 0022-2593 .- 1468-6244. ; 51:9, s. 563-572
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Abstract
Ämnesord
Stäng
- Mammalian experiments provide clear evidence of male line transgenerational effects on health and development from paternal or ancestral early-life exposures such as diet or stress. The few human observational studies to date suggest (male line) transgenerational effects exist that cannot easily be attributed to cultural and/or genetic inheritance. Here we summarise relevant studies, drawing attention to exposure sensitive periods in early life and sex differences in transmission and offspring outcomes. Thus, variation, or changes, in the parental/ancestral environment may influence phenotypic variation for better or worse in the next generation(s), and so contribute to common, non-communicable disease risk including sex differences. We argue that life-course epidemiology should be reframed to include exposures from previous generations, keeping an open mind as to the mechanisms that transmit this information to offspring. Finally, we discuss animal experiments, including the role of epigenetic inheritance and non-coding RNAs, in terms of what lessons can be learnt for designing and interpreting human studies. This review was developed initially as a position paper by the multidisciplinary Network in Epigenetic Epidemiology to encourage transgenerational research in human cohorts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Epigenetics
- epigenetic epidemiology
- miRNAs
- overkalix
- transgenerational
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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