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Total and Trimester...
Total and Trimester-Specific Gestational Weight Gain and Offspring Birth and Early Childhood Weight : A Prospective Cohort Study on Monozygotic Twin Mothers and Their Offspring
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- Scheers Andersson, Elina (författare)
- Karolinska Institutet
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- Silventoinen, Karri (författare)
- University of Helsinki, Helsinki, Finland
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- Tynelius, Per (författare)
- Karolinska Institutet
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- Nohr, Ellen A (författare)
- University of Southern Denmark, Odense, Denmark
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- Sørensen, Thorkild I A (författare)
- University of Copenhagen, Copenhagen, Denmark / Bispebjerg and Frederiksberg Hospital, Copenhagen, The Capital Region, Denmark / Bristol University, Bristol, UK
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- Rasmussen, Finn (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-05-10
- 2016
- Engelska.
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Ingår i: Twin Research and Human Genetics. - : Cambridge University Press (CUP). - 1832-4274 .- 1839-2628. ; 19:4, s. 367-76
- Relaterad länk:
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https://helda.helsin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Gestational weight gain (GWG) has in numerous studies been associated with offspring birth weight (BW) and childhood weight. However, these associations might be explained by genetic confounding as offspring inherit their mother's genetic potential to gain weight. Furthermore, little is known about whether particular periods of pregnancy could influence offspring body weight differently. We therefore aimed to explore total and trimester-specific effects of GWG in monozygotic (MZ) twin mother-pairs on their offspring's BW, weight at 1 year and body mass index (BMI) at 5 and 10 years. MZ twin mothers born 1962-1975 were identified in national Swedish registers, and data on exposure and outcome variables was collected from medical records. We analyzed associations within and between twin pairs. We had complete data on the mothers' GWG and offspring BW for 82 pairs. The results indicated that total, and possibly also second and third trimester GWG were associated with offspring BW within the twin pairs in the fully adjusted model (β = 0.08 z-score units, 95% CI: 0.001, 0.17; β = 1.32 z-score units, 95% CI: -0.29, 2.95; and β = 1.02 z-score units, 95% CI: -0.50, 2.54, respectively). Our findings, although statistically weak, suggested no associations between GWG and offspring weight or BMI during infancy or childhood. Our study suggests that total, and possibly also second and third trimester, GWG are associated with offspring BW when taking shared genetic and environmental factors within twin pairs into account. Larger family-based studies with long follow-up are needed to confirm our findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- birth weight
- childhood body weight
- genetics
- gestational trimester
- gestational weight gain
- monozygotic twins
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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