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HAT-HDAC interplay ...
HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress
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- Johnsson, Anna (författare)
- Södertörns högskola,Molekylärbiologi,Karolinska Institutet
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- Durand-Dubief, Mickael (författare)
- Karolinska Institutet
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- Xue-Franzen, Yongtao (författare)
- Södertörns högskola,Molekylärbiologi,Karolinska Institutet
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- Rönnerblad, Michelle (författare)
- Karolinska Institutet
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- Ekwall, Karl (författare)
- Södertörns högskola,Molekylärbiologi,Karolinska Institutet
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- Wright, Anthony P. H. (författare)
- Södertörns högskola,Molekylärbiologi,Karolinska Institutet
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(creator_code:org_t)
- 2009-07-24
- 2009
- Engelska.
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Ingår i: EMBO Reports. - : EMBO. - 1469-221X .- 1469-3178. ; 10:9, s. 1009-1014
- Relaterad länk:
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http://www.ncbi.nlm....
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Histone acetylation and deacetylation are important for gene regulation. The histone acetyltransferase, Gcn5, is an activator of transcriptional initiation that is recruited to gene promoters. Here, we map genome-wide Gcn5 occupancy and histone H3K14ac at high resolution. Gcn5 is predominantly localized to coding regions of highly transcribed genes, where it collaborates antagonistically with the class-II histone deacetylase, Clr3, to modulate H3K14ac levels and transcriptional elongation. An interplay between Gcn5 and Clr3 is crucial for the regulation of many stress-response genes. Our findings suggest a new role for Gcn5 during transcriptional elongation, in addition to its known role in transcriptional initiation.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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