Enantioselective α-arylation of cyclohexanones with diaryl iodonium salts : Application to the synthesis of (-)-epibatidine.

• The direct asym. α-arylation of prochiral ketones has been effected using chiral lithium amide bases and diaryl iodonium salts. The methodol. has been employed in a short total synthesis of the alkaloid (-)-epibatidine. [on SciFinder(R)]

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

epibatidine synthesis enantioselective arylation

cyclohexanone diaryl iodonium enantioselective alpha arylation

organisk kemi

Organic Chemistry

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