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Case Study on Scree...
Case Study on Screening Emerging Pollutants in Urine and Nails
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Alves, Andreia (författare)
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- Giovanoulis, Georgios (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Swedish Environmental Research Institute, Sweden
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- Nilsson, Ulrika (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
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Erratico, Claudio (författare)
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Lucattini, Luisa (författare)
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Haug, Line S. (författare)
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Jacobs, Griet (författare)
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- de Wit, Cynthia A. (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
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Leonards, Pim E. G. (författare)
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Covaci, Adrian (författare)
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Magner, Jorgen (författare)
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Voorspoels, Stefan (författare)
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(creator_code:org_t)
- 2017-03-22
- 2017
- Engelska.
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 51:7, s. 4046-4053
- Relaterad länk:
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https://repository.u...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Alternative plasticizers and flame retardants (FRs) have been introduced as replacements for banned or restricted chemicals, but much is still unknown about their metabolism and occurrence in humans. We identified the metabolites formed in vitro for four alternative plasticizers (acetyltributyl citrate (ATBC), bis(2-propylheptyl) phthalate (DPHP), bis(2-ethylhexyl) terephthalate (DEHTP), bis(2ethylhexyl) adipate (DEHA)), and one FR (2,2-bis (chloromethyl)-propane-1,3-diyltetrakis(2-chloroethyl) bisphosphate (V6)). Further, these compounds and their metabolites were investigated by LC/ESI-Orbitrap-MS in urine and finger nails collected from a Norwegian cohort. Primary and secondary ATBC metabolites had detection frequencies (% DF) in finger nails ranging from 46 to 95%. V6 was identified for the first time in finger nails, suggesting that this matrix may also indicate past exposure to FRs as well as alternative plasticizers. Two isomeric forms of DEHTP primary metabolite were highly detected in urine (97% DF) and identified in finger nails, while no DPHP metabolites were detected in vivo. Primary and secondary DEHA metabolites were identified in both matrices, and the relative proportion of the secondary metabolites was higher in urine than in finger nails; the opposite was observed for the primary metabolites. As many of the metabolites present in in vitro extracts were further identified in vivo in urine and finger nail samples, this suggests that in vitro assays can reliably mimic the in vivo processes. Finger nails may be a useful noninvasive matrix for human biomonitoring of specific organic contaminants, but further validation is needed.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Naturresursteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Environmental Engineering (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
Nyckelord
- Applied Environmental Science
- tillämpad miljövetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Alves, Andreia
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Giovanoulis, Geo ...
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Nilsson, Ulrika
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Erratico, Claudi ...
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Lucattini, Luisa
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Haug, Line S.
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visa fler...
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Jacobs, Griet
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de Wit, Cynthia ...
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Leonards, Pim E. ...
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Covaci, Adrian
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Magner, Jorgen
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Voorspoels, Stef ...
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visa färre...
- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Naturresurstekni ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
- Artiklar i publikationen
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Environmental Sc ...
- Av lärosätet
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Stockholms universitet