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Amorphous Calcium C...
Amorphous Calcium Carbonate Constructed from Nanoparticle Aggregates with Unprecedented Surface Area and Mesoporosity
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- Sun, Rui (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Zhang, Peng (författare)
- Uppsala universitet,Stockholms universitet,Institutionen för material- och miljökemi (MMK),Uppsala University, Sweden,Nanoteknologi och funktionella material,Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden,Nanotechnology and Functional Materials
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- Bajnócz, Éva G. (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences
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- Neagu, Alexandra (författare)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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- Tai, Cheuk-Wai (författare)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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- Persson, Ingmar (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences
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- Strömme, Maria, 1970- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Cheung, Ocean (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
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- 2018-06-04
- 2018
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 10:25, s. 21556-21564
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- Amorphous calcium carbonate (ACC), with the highest reported specific surface area of all current forms of calcium carbonate (over 350 m(2) g(-1)), was synthesized using a surfactant-free, one-pot method. Electron microscopy, helium pycnometry, and nitrogen sorption analysis revealed that this highly mesoporous ACC, with a pore volume of similar to 0.86 cm(3) g(-1) and a pore-size distribution centered at 8-9 nm, is constructed from aggregated ACC nanoparticles with an estimated average diameter of 7.3 nm. The porous ACC remained amorphous and retained its high porosity for over 3 weeks under semi-air-tight storage conditions. Powder X-ray diffraction, large-angle X-ray scattering, infrared spectroscopy, and electron diffraction exposed that the porous ACC did not resemble any of the known CaCO3 structures. The atomic order of porous ACC diminished at interatomic distances over 8 angstrom. Porous ACC was evaluated as a potential drug carrier of poorly soluble substances in vitro. Itraconazole and celecoxib remained stable in their amorphous forms within the pores of the material. Drug release rates were significantly enhanced for both drugs (up to 65 times the dissolution rates for the crystalline forms), and supersaturation release of celecoxib was also demonstrated. Citric acid was used to enhance the stability of the ACC nanoparticles within the aggregates, which increased the surface area of the material to over 600 m(2) g(-1). This porous ACC has potential for use in various applications where surface area is important, including adsorption, catalysis, medication, and bone regeneration.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Nyckelord
- amorphous calcium carbonate
- large-angle X-ray scattering
- porous materials
- drug delivery
- nanoparticles
- Engineering Science with specialization in Nanotechnology and Functional Materials
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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