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Coordination Modula...
Coordination Modulation Method To Prepare New Metal-Organic Framework-Based CO-Releasing Materials
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Carmona, Francisco J. (författare)
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Maldonado, Carmen R. (författare)
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Ikemura, Shuya (författare)
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Romao, Carlos C. (författare)
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- Huang, Zhehao (författare)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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- Xu, Hongyi (författare)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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- Zou, Xiaodong (författare)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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Kitagawa, Susumu (författare)
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Furukawa, Shuhei (författare)
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Barea, Elisa (författare)
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(creator_code:org_t)
- 2018-08-28
- 2018
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 10:37, s. 31158-31167
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aluminum-based metal organic frameworks (MOFs), [Al(OH)(SDC)](n), (H2SDC: 4,4'-stilbenedicarboxylic acid), also known as CYCU-3, were prepared by means of the coordination modulation method to produce materials with different crystal size and morphology. In particular, we screened several reagent concentrations (20-60 mM) and modulator/ligand ratios (0-50), leading to 20 CYCU x_y materials (x: reagent concentration, y = modulator/ligand ratio) with different particle size and morphology. Noteworthy, the use of high modulator/ligand ratio gives rise to a new phase of CYCU-3 (CYCU-3' x_50 series), which was structurally analyzed. Afterward, to test the potential of these materials as CO-prodrug carriers, we selected three of them to adsorb the photo- and bioactive CO-releasing molecule (CORM) ALF794 [Mo(CNCMe2CO2H)(3)(CO)(3)] (CNCMe2CO2H = 2-isocyano-2-methyl propionic acid): (i) CYCU-3 20_0, particles in the nanometric range; (ii) CYCU-3 50_5, bar-type particles with heterogeneous size, and (iii) CYCU-3' 50_50, a new phase analogous to pristine CYCU-3. The corresponding hybrid materials were fully characterized, revealing that CYCU-3 20_0 with the smallest particle size was not stable under the drug loading conditions. Regarding the other two materials, similar ALF794 loadings were found (0.20 and 0.19 CORM/MOF molar ratios for ALF794@CYCU-3 50_5 and ALF794@CYCU-3' 50_50, respectively). In addition, these hybrid systems behave as CO-releasing materials (CORMAs), retaining the photoactive properties of the pristine CORM in both phosphate saline solution and solid state. Finally, the metal leaching studies in solution confirmed that ALF794@CYCU-3' 50_50 shows a good retention capacity toward the potentially toxic molybdenum fragments (7S% of retention after 72 h), which is the lowest value reported for a MOF-based CORMA to date.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- carbon monoxide
- metal-organic framework
- solid-state materials
- guest inclusion
- continuous rotation electron diffraction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Carmona, Francis ...
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Maldonado, Carme ...
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Ikemura, Shuya
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Romao, Carlos C.
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Huang, Zhehao
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Xu, Hongyi
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visa fler...
-
Zou, Xiaodong
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Kitagawa, Susumu
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Furukawa, Shuhei
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Barea, Elisa
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visa färre...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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ACS Applied Mate ...
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Stockholms universitet