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Estimation of model...
Estimation of model accuracy in CASP13
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- Cheng, Jianlin (author)
- Univ Missouri, MO USA
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- Choe, Myong‐Ho (author)
- Univ Sci, North Korea
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- Elofsson, Arne (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Sweden
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- Han, Kun-Sop (author)
- Univ Sci, North Korea
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- Hou, Jie (author)
- Univ Missouri, MO USA
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- Maghrabi, Ali H. A. (author)
- Univ Reading, England
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- McGuffin, Liam J. (author)
- Univ Reading, England
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- Menéndez-Hurtado, David (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Sweden
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- Olechnovič, Kliment (author)
- Vilnius Univ, Lithuania
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- Schwede, Torsten (author)
- Univ Basel, Switzerland
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- Studer, Gabriel (author)
- Univ Basel, Switzerland; Univ Basel, Switzerland
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- Uziela, Karolis (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Sweden
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- Venclovas, Česlovas (author)
- Vilnius Univ, Lithuania
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- Wallner, Björn (author)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten
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(creator_code:org_t)
- 2019-07-16
- 2019
- English.
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In: Proteins. - : Wiley. - 0887-3585 .- 1097-0134. ; 87:12, s. 1361-1377
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https://urn.kb.se/re...
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Abstract
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- Methods to reliably estimate the accuracy of 3D models of proteins are both a fundamental part of most protein folding pipelines and important for reliable identification of the best models when multiple pipelines are used. Here, we describe the progress made from CASP12 to CASP13 in the field of estimation of model accuracy (EMA) as seen from the progress of the most successful methods in CASP13. We show small but clear progress, that is, several methods perform better than the best methods from CASP12 when tested on CASP13 EMA targets. Some progress is driven by applying deep learning and residue‐residue contacts to model accuracy prediction. We show that the best EMA methods select better models than the best servers in CASP13, but that there exists a great potential to improve this further. Also, according to the evaluation criteria based on local similarities, such as lDDT and CAD, it is now clear that single model accuracy methods perform relatively better than consensus‐based methods.
Subject headings
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Keyword
- Biochemistry towards Bioinformatics
- biokemi med inriktning mot bioinformatik
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Cheng, Jianlin
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Choe, Myong‐Ho
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Elofsson, Arne
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Han, Kun-Sop
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Hou, Jie
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Maghrabi, Ali H. ...
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show more...
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McGuffin, Liam J ...
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Menéndez-Hurtado ...
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Olechnovič, Klim ...
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Schwede, Torsten
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Studer, Gabriel
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Uziela, Karolis
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Venclovas, Česlo ...
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Wallner, Björn
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
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Proteins
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Stockholm University
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Linköping University