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High-resolution mas...
High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples
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Liu, Yanna (författare)
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- D'Agostino, Lisa A. (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Science for Life Laboratory (SciLifeLab)
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Qu, Guangbo (författare)
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Jiang, Guibin (författare)
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- Martin, Jonathan W. (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Science for Life Laboratory (SciLifeLab)
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: TrAC. Trends in analytical chemistry. - : Elsevier BV. - 0165-9936 .- 1879-3142. ; 121
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Widespread environmental contamination of legacy long-chain poly- and per-fluoroalkyl substances (PFASs) has triggered chemical regulatory action and a global transitioning to alternative PFASs. More than 5000 PFASs are now recognized on various lists, but few have been monitored despite ample evidence of unidentified organic fluorine in human and environmental samples. Nevertheless, our review of the literature indicates that nontarget analytical methods based on high-resolution mass spectrometry have been used to discover more than 750 PFASs, belonging to more than 130 diverse classes, in strategically selected environmental samples, biofluids or commercial products. Among these reports, we summarize the analytical and data-processing strategies for nontarget PFAS discovery, identify knowledge gaps and propose new areas for method development. Discovery of emerging PFASs before they are global contaminants could mitigate future contamination if strategic techniques can be developed to prioritize some of these substances for synthesis and confirmation, further monitoring, source elucidation and hazard characterization.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- High-resolution mass spectrometry (HRMS)
- Poly-/per-fluoroalkyl substances (PFASs)
- Nontarget discovery
- PFAS-Feature identification
- Suspect screening
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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