Sökning: id:"swepub:oai:DiVA.org:su-179698" >
UCP1-independent gl...
UCP1-independent glucose-lowering effect of leptin in type 1 diabetes : only in conditions of hypoleptinemia
-
- Zouhar, Petr (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Institute of Physiology CAS, the Czech Republic
-
Rakipovski, Gunaj (författare)
-
- Bokhari, Muhammad Hamza (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
-
visa fler...
-
- Busby, Oliver (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
-
Paulsson, Johan F. (författare)
-
Conde-Frieboes, Kilian W. (författare)
-
Fels, Johannes J. (författare)
-
Raun, Kirsten (författare)
-
Andersen, Birgitte (författare)
-
- Cannon, Barbara (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
-
- Nedergaard, Jan (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
-
visa färre...
-
(creator_code:org_t)
- American Physiological Society, 2020
- 2020
- Engelska.
-
Ingår i: American Journal of Physiology. Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 318:1, s. E72-E86
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://journals.phy...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The possibility to use leptin therapeutically for lowering glucose levels in patients with type 1 diabetes has attracted interest. However, earlier animal models of type 1 diabetes are severely catabolic with very low endogenous leptin levels, unlike most patients with diabetes. Here, we aim to test glucose-lowering effects of leptin in novel, more human-like murine models. We examined the glucose-lowering potential of leptin in diabetic models of two types: streptozotocin-treated mice and mice treated with the insulin receptor antagonist S961. To prevent hypoleptinemia, we used combinations of thermoneutral temperature and high-fat feeding. Leptin fully normalized hyperglycemia in standard chow-fed streptozotocin-treated diabetic mice. However, more humanized physiological conditions (high-fat diets or thermoneutral temperatures) that increased adiposity- and thus also leptin level-sin the diabetic mice abrogated the effects of leptin, i.e., the mice developed leptin resistance also in this respect. The glucose-lowering effect of leptin was not dependent on the presence of the uncoupling protein-1 and was not associated with alterations in plasma insulin, insulin-like growth factor 1, food intake or corticosterone but fully correlated with decreased plasma glucagon levels and gluconeogenesis. An important implication of these observations is that the therapeutic potential of leptin as an additional treatment in patients with type 1 diabetes is probably limited. This is because such patients are treated with insulin and do not display low leptin levels. Thus, the potential for a glucose-lowering effect of leptin would already have been attained with standard insulin therapy, and further effects on blood glucose level through additional leptin cannot be anticipated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- glucagon
- insulin receptor antagonist
- leptin
- thermoneutrality
- type 1 diabetes
- uncoupling protein 1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Zouhar, Petr
-
Rakipovski, Guna ...
-
Bokhari, Muhamma ...
-
Busby, Oliver
-
Paulsson, Johan ...
-
Conde-Frieboes, ...
-
visa fler...
-
Fels, Johannes J ...
-
Raun, Kirsten
-
Andersen, Birgit ...
-
Cannon, Barbara
-
Nedergaard, Jan
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
American Journal ...
- Av lärosätet
-
Stockholms universitet