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Structure and genet...
Structure and genetics of Escherichia coli O antigens
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Liu, Bin (författare)
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- Furevi, Axel (författare)
- Stockholms universitet,Institutionen för organisk kemi
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Perepelov, Andrei (författare)
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Guo, Xi (författare)
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Cao, Hengchun (författare)
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Wang, Quan (författare)
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Reeves, Peter R. (författare)
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Knirel, Yuriy A. (författare)
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Wang, Lei (författare)
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- Widmalm, Göran (författare)
- Stockholms universitet,Institutionen för organisk kemi
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visa färre...
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(creator_code:org_t)
- 2019-11-28
- 2020
- Engelska.
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Ingår i: FEMS Microbiology Reviews. - : Oxford University Press (OUP). - 0168-6445 .- 1574-6976. ; 44:6, s. 655-683
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Escherichia coli includes clonal groups of both commensal and pathogenic strains, with some of the latter causing serious infectious diseases. O antigen variation is current standard in defining strains for taxonomy and epidemiology, providing the basis for many serotyping schemes for Gram-negative bacteria. This review covers the diversity in E. coli O antigen structures and gene clusters, and the genetic basis for the structural diversity. Of the 187 formally defined O antigens, six (O31, O47, O67, O72, O94 and O122) have since been removed and three (O34, O89 and O144) strains do not produce any O antigen. Therefore, structures are presented for 176 of the 181 E. coli O antigens, some of which include subgroups. Most (93%) of these O antigens are synthesized via the Wzx/Wzy pathway, 11 via the ABC transporter pathway, with O20, O57 and O60 still uncharacterized due to failure to find their O antigen gene clusters. Biosynthetic pathways are given for 38 of the 49 sugars found in E. coli O antigens, and several pairs or groups of the E. coli antigens that have related structures show close relationships of the O antigen gene clusters within clades, thereby highlighting the genetic basis of the evolution of diversity.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Escherichia coli
- O antigen
- gene cluster
- serogroup
- diversity
- structure
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Liu, Bin
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Furevi, Axel
-
Perepelov, Andre ...
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Guo, Xi
-
Cao, Hengchun
-
Wang, Quan
-
visa fler...
-
Reeves, Peter R.
-
Knirel, Yuriy A.
-
Wang, Lei
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Widmalm, Göran
-
visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
- Artiklar i publikationen
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FEMS Microbiolog ...
- Av lärosätet
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Stockholms universitet