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Brain integrity is ...
Brain integrity is altered by hepatic APOEε4 in humanized-liver mice
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- Giannisis,, Andreas (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Patra, Kalicharan (author)
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- Edlund, Anna, 1983- (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Agirrezabala Nieto, Lur (author)
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Benedicto-Gras, Joan (author)
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Moussaud, Simon (author)
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De La Rosa, Andrés (author)
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Twohig, Daniel (author)
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Bengtsson, Tore (author)
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Fu, Yuan (author)
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Bu, Guojun (author)
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Bial, Greg (author)
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Foquet, Lander (author)
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Raber, Jacob (author)
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Hammarstedt, Christina (author)
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Strom, Stephen (author)
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Kannisto, Kristina (author)
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Ellis, Ewa (author)
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- Nielsen,, Henrietta M. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Henrietta Nielsen
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
Close
- Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer’s disease (AD) risk and AD biomarker levels. Carriers of APOEε4, the strongest genetic AD risk factor, exhibit lower plasma apoE and altered brain integrity already at mid-life versus non-APOEε4 carriers. Whether altered plasma liver-derived apoE or specifically an APOEε4 liver phenotype promotes brain injury and neurodegeneration is unknown. Here we investigated the brains of Fah-/-, Rag2-/-, Il2rg-/- mice on the Non-Obese Diabetic (NOD) background (FRGN) with humanized-livers of an AD risk-associated APOE ε4/ε4 versus an APOE ε2/ε3 genotype. Reduced endogenous mouse apoE levels in the brains of APOE ε4/ε4 liver mice were accompanied by various changes in markers of synaptic integrity, neuroinflammation, and insulin signaling. Plasma apoE4 levels were associated with unfavorable changes in several of the assessed markers. These results propose a previously unexplored role of the liver in the APOEε4-associated risk neurodegenerative diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- neurokemi med molekylär neurobiologi
- Neurochemistry with Molecular Neurobiology
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Giannisis,, Andr ...
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Patra, Kalichara ...
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Edlund, Anna, 19 ...
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Agirrezabala Nie ...
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Benedicto-Gras, ...
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Moussaud, Simon
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show more...
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De La Rosa, Andr ...
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Twohig, Daniel
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Bengtsson, Tore
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Fu, Yuan
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Bu, Guojun
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Bial, Greg
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Foquet, Lander
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Raber, Jacob
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Hammarstedt, Chr ...
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Strom, Stephen
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Kannisto, Kristi ...
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Ellis, Ewa
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Nielsen,, Henrie ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- By the university
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Stockholm University