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Visible Light Mediated Photocatalytic N‑Radical Cascade Reactivity of γ,δ-Unsaturated N‑Arylsulfonylhydrazones : A General Approach to Structurally Diverse Tetrahydropyridazines
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Azzi, Emanuele (författare)
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Ghigo, Giovanni (författare)
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- Parisotto, Stefano (författare)
- Stockholms universitet,Institutionen för organisk kemi,University of Torino, Italy
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Pellegrino, Francesco (författare)
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Priola, Emanuele (författare)
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Renzi, Polyssena (författare)
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Deagostino, Annamaria (författare)
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(creator_code:org_t)
- 2021-02-01
- 2021
- Engelska.
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 86:4, s. 3300-3323
- Relaterad länk:
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https://iris.unito.i...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Tetrahydropyridazines are of particular interest for their versatility as intermediates in organic synthesis and display pharmacological activity in several domains. Here, we describe the photocatalytic synthesis of different tetrahydropyridazines starting from gamma,delta-unsaturated N-arylsulfonylhydrazones. Simple structural changes of substrates result into three different pathways beginning from a common N-hydrazonyl radical, which evolves through a domino carboamination/dearomatization, a HAT process, or a photoinduced radical Smiles rearrangement to afford diverse tetrahydropyridazines. All reactions are carried out in very mild conditions, and the quite inexpensive [Ru(bpy)(3)]Cl-2 is used as the catalyst. Preliminary mechanism studies are presented, among them luminescence and electrochemical characterization of the involved species. Computational studies allow to rationalize the mechanism in accord with the experimental findings.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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