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Multi-omics persona...
Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity
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- Ambikan, Anoop T. (author)
- Karolinska Institutet
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- Yang, Hong (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Krishnan, Shuba (author)
- Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Syst Virol Lab, Stockholm S-14152, Sweden.
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- Svensson Akusjarvi, Sara (author)
- Karolinska Institutet
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- Gupta, Soham (author)
- Karolinska Institutet
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- Lourda, Magda (author)
- Karolinska Institutet
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- Sperk, Maike (author)
- Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Syst Virol Lab, Stockholm S-14152, Sweden.
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- Arif, Muhammad (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Zhang, Cheng (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Nordqvist, Hampus (author)
- South Gen Hosp, Sodersjukhuset, S-11883 Stockholm, Sweden.
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- Ponnan, Sivasankaran Munusamy (author)
- Fred Hutchinson Canc Res Ctr FHCRC, HIV Vaccine Trials Network, Vaccine & Infect Dis, Seattle, WA 98109 USA.
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- Sonnerborg, Anders (author)
- Karolinska Institutet
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- Treutiger, Carl Johan (author)
- Karolinska Univ Hosp, Karolinska Inst, Dept Med Huddinge, Div Infect Dis, I73, S-14186 Huddinge, Stockholm, Sweden.
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- O'Mahony, Liam (author)
- Natl Univ Ireland, Univ Coll Cork, Sch Microbiol, Cork T12YN60, Ireland.;Natl Univ Ireland, Univ Coll Cork, APC Microbiome Ireland, Cork T12YN60, Ireland.;Natl Univ Ireland, Univ Coll Cork, Dept Med, Cork T12YN60, Ireland.
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- Mardinoglu, Adil (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London WC2RLS, England.
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- Benfeitas, Rui (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Natl Bioinformat Infrastructure Sweden NBIS, S-10691 Stockholm, Sweden.
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- Neogi, Ujjwal (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Cell systems. - : Elsevier BV. - 2405-4712 .- 2405-4720. ; 13:8, s. 665-681
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Abstract
Subject headings
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- The clinical outcome and disease severity in coronavirus disease 2019 (COVID-19) are heterogeneous, and the progression or fatality of the disease cannot be explained by a single factor like age or comorbidities. In this study, we used system-wide network-based system biology analysis using whole blood RNA sequencing, immunophenotyping by flow cytometry, plasma metabolomics, and single-cell-type metabolo-mics of monocytes to identify the potential determinants of COVID-19 severity at personalized and group levels. Digital cell quantification and immunophenotyping of the mononuclear phagocytes indicated a sub-stantial role in coordinating the immune cells that mediate COVID-19 severity. Stratum-specific and person-alized genome-scale metabolic modeling indicated monocarboxylate transporter family genes (e.g., SLC16A6), nucleoside transporter genes (e.g., SLC29A1), and metabolites such as a-ketoglutarate, succi-nate, malate, and butyrate could play a crucial role in COVID-19 severity. Metabolic perturbations targeting the central metabolic pathway (TCA cycle) can be an alternate treatment strategy in severe COVID-19.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- COVID-19
- similarity network fusion
- personalized genome-scale metabolic model
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ambikan, Anoop T ...
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Yang, Hong
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Krishnan, Shuba
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Svensson Akusjar ...
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Gupta, Soham
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Lourda, Magda
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show more...
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Sperk, Maike
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Arif, Muhammad
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Zhang, Cheng
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Nordqvist, Hampu ...
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Ponnan, Sivasank ...
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Sonnerborg, Ande ...
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Treutiger, Carl ...
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O'Mahony, Liam
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Mardinoglu, Adil
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Benfeitas, Rui
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Neogi, Ujjwal
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Cell systems
- By the university
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Stockholm University
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Royal Institute of Technology
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Karolinska Institutet