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Sökning: id:"swepub:oai:DiVA.org:su-215086" > Single-Cell Transcr...

Single-Cell Transcriptomics To Define Plasmodium falciparum Stage Transition in the Mosquito Midgut

Mohammed, Mubasher, Msc (författare)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
Dziedziech, Alexis, 1991- (författare)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
Sekar, Vaishnovi (författare)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory (SciLifeLab),Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden.
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Ernest, Medard (författare)
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, Rockville, United States,NIH, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Rockville, MD 20892 USA.
Alves E Silva, Thiago Luiz (författare)
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, Rockville, United States,NIH, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Rockville, MD 20892 USA.
Balan, Balu (författare)
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, VIC, Melbourne, Australia; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, VIC, Parkville, Australia,Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia.;Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia.
Emami, S. Noushin (författare)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
Biryukova, Inna (författare)
Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden.
Friedländer, Marc R. (författare)
Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut,Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden.
Jex, Aaron (författare)
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, VIC, Melbourne, Australia; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, VIC, Parkville, Australia,Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia.;Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia.
Jacobs-Lorena, Marcelo (författare)
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, MD, Baltimore, United States,Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA.
Henriksson, Johan (författare)
Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Univ, Dept Mol Biol, Lab Mol Infect Med Sweden MIMS, Umeå, Sweden.
Vega-Rodriguez, Joel (författare)
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, Rockville, United States,NIH, Natl Inst Allergy & Infect Dis, Lab Malaria & Vector Res, Rockville, MD 20892 USA.
Ankarklev, Johan (författare)
Uppsala universitet,Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; Microbial Single Cell Genomics, Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden,Science for Life Laboratory, SciLifeLab,Molekylär evolution,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden
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 (creator_code:org_t)
2023-02-27
2023
Engelska.
Ingår i: Microbiology Spectrum. - : American Society for Microbiology. - 2165-0497. ; 11:2
Relaterad länk:
https://doi.org/10.1...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Malaria inflicts the highest rate of morbidity and mortality among the vector-borne diseases. The dramatic bottleneck of parasite numbers that occurs in the gut of the obligatory mosquito vector provides a promising target for novel control strategies. Using single-cell transcriptomics, we analyzed Plasmodium falciparum development in the mosquito gut, from unfertilized female gametes through the first 20 h after blood feeding, including the zygote and ookinete stages. This study revealed the temporal gene expression of the ApiAP2 family of transcription factors and of parasite stress genes in response to the harsh environment of the mosquito midgut. Further, employing structural protein prediction analyses, we found several upregulated genes predicted to encode intrinsically disordered proteins (IDPs), a category of proteins known for their importance in regulation of transcription, translation, and protein-protein interactions. IDPs are known for their antigenic properties and may serve as suitable targets for antibody- or peptide-based transmission suppression strategies. In total, this study uncovers the P. falciparum transcriptome from early to late parasite development in the mosquito midgut, inside its natural vector, which provides an important resource for future malaria transmission-blocking initiatives.

Ämnesord

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Mikrobiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Microbiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

malaria
Plasmodium falciparum
mosquito midgut
scRNA-seq
single cell
stage transition
transmission
molekylär biovetenskap
Molecular Bioscience

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