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Objectively-measure...
Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults : a population-based study
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- Wang, Yongxiang (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong University, Jinan, People’s Republic of China
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Han, Qi (författare)
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Han, Xiaolei (författare)
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Dong, Yi (författare)
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Mao, Ming (författare)
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Wang, Chaoqun (författare)
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Wang, Xiaojie (författare)
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Tang, Shi (författare)
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- Liu, Cuicui (författare)
- Karolinska Institutet
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- Li, Yuanjing (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Hou, Tingting (författare)
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Cong, Lin (författare)
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Du, Yifeng (författare)
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- Qiu, Chengxuan (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong Provincial Hospital affiliated to Shandong First Medical University, People’s Republic of China
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Immunity & Ageing. - 1742-4933. ; 20:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundEvidence has linked self-reported sedentary behavior (SB) and physical activity (PA) with cognitive impairment; however, the underlying mechanisms are poorly understood. We examined the associations of the accelerometer-measured movement behaviors with plasma neurofilament light chain (NfL) among older adults and the role of systemic low-grade inflammation in the associations.ResultsThis population-based study included 1,029 dementia-free older adults (age & GE; 60 years, range 60-88 years; 59.48% women) who undertook the ActiGraph substudy (March 2018-December 2020) in MIND-China. There were nonlinear relationships of daily SB and PA time with plasma NfL concentration, such that more daily SB time or less time spent in daily light-intensity physical activity (LPA) and moderate-to-vigorous-intensity physical activity (MVPA) was significantly associated with increased plasma NfL only when SB time & GE; 8.00 h/day or LPA time < 5.00 h/day or MVPA time < 2.00 h/day. Furthermore, more daily SB time or less daily LPA and MVPA time was significantly associated with higher serum low-grade inflammation score, a composite measure generated from serum IL-6, IL-8, TNF-& alpha;, and ICAM-1 (P < 0.05). Finally, low-grade inflammation score accounted for 14.5% to 17.8% of the associations between movement behaviors and plasma NfL.ConclusionsMore daily SB and less PA time are associated with neurodegeneration and systemic low-grade inflammation in older adults. The association of movement behaviors with neurodegeneration is partially mediated by low-grade inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Nyckelord
- Accelerometer
- Movement behaviors
- Neurofilament light chain
- Low-grade inflammation
- Population-based study
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wang, Yongxiang
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Han, Qi
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Han, Xiaolei
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Dong, Yi
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Mao, Ming
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Wang, Chaoqun
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visa fler...
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Wang, Xiaojie
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Tang, Shi
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Liu, Cuicui
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Li, Yuanjing
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Hou, Tingting
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Cong, Lin
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Du, Yifeng
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Qiu, Chengxuan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
- Artiklar i publikationen
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Immunity & Agein ...
- Av lärosätet
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Stockholms universitet
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Karolinska Institutet