Sökning: id:"swepub:oai:DiVA.org:umu-102363" >
Mortality amongst P...
Mortality amongst Patients with Influenza-Associated Severe Acute Respiratory Illness, South Africa, 2009-2013
-
Cohen, Cheryl (författare)
-
Moyes, Jocelyn (författare)
-
Tempia, Stefano (författare)
-
visa fler...
-
Groome, Michelle (författare)
-
Walaza, Sibongile (författare)
-
Pretorius, Marthi (författare)
-
Dawood, Halima (författare)
-
Chhagan, Meera (författare)
-
Haffejee, Summaya (författare)
-
Variava, Ebrahim (författare)
-
- Kahn, Kathleen (författare)
- Umeå universitet,Epidemiologi och global hälsa,Centre for Global Health Research
-
von Gottberg, Anne (författare)
-
Wolter, Nicole (författare)
-
Cohen, Adam L. (författare)
-
Malope-Kgokong, Babatyi (författare)
-
Venter, Marietjie (författare)
-
Madhi, Shabir A. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2015-03-18
- 2015
- Engelska.
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:3
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://journals.plo...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Introduction Data on the burden and risk groups for influenza-associated mortality from Africa are limited. We aimed to estimate the incidence and risk-factors for in-hospital influenza-associated severe acute respiratory illness (SARI) deaths.Methods Hospitalised patients with SARI were enrolled prospectively in four provinces of South Africa from 2009-2013. Using polymerase chain reaction, respiratory samples were tested for ten respiratory viruses and blood for pneumococcal DNA. The incidence of influenza-associated SARI deaths was estimated at one urban hospital with a defined catchment population.Results We enrolled 1376 patients with influenza-associated SARI and 3% (41 of 1358 with available outcome data) died. In patients with available HIV-status, the case-fatality proportion (CFP) was higher in HIV-infected (5%, 22/419) than HIV-uninfected individuals (2%, 13/620; p = 0.006). CFPs varied by age group, and generally increased with increasing age amongst individuals >5 years (p<0.001). On multivariable analysis, factors associated with death were age-group 45-64 years (odds ratio (OR) 4.0, 95% confidence interval (CI) 1.01-16.3) and >= 65 years (OR 6.5, 95% CI 1.2-34.3) compared to 1-4 year age-group who had the lowest CFP, HIV-infection (OR 2.9, 95% CI 1.1-7.8), underlying medical conditions other than HIV (OR 2.9, 95% CI 1.2-7.3) and pneumococcal co-infection (OR 4.1, 95% CI 1.5-11.2). The estimated incidence of influenza-associated SARI deaths per 100,000 population was highest in children <1 year (20.1, 95% CI 12.1-31.3) and adults aged 45-64 years (10.4, 95% CI 8.4-12.9). Adjusting for age, the rate of death was 20-fold (95% CI 15.0-27.8) higher in HIV-infected individuals than HIV-uninfected individuals.Conclusion Influenza causes substantial mortality in urban South Africa, particularly in infants aged <1 year and HIV-infected individuals. More widespread access to antiretroviral treatment and influenza vaccination may reduce this burden.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
PLOS ONE
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Cohen, Cheryl
-
Moyes, Jocelyn
-
Tempia, Stefano
-
Groome, Michelle
-
Walaza, Sibongil ...
-
Pretorius, Marth ...
-
visa fler...
-
Dawood, Halima
-
Chhagan, Meera
-
Haffejee, Summay ...
-
Variava, Ebrahim
-
Kahn, Kathleen
-
von Gottberg, An ...
-
Wolter, Nicole
-
Cohen, Adam L.
-
Malope-Kgokong, ...
-
Venter, Marietji ...
-
Madhi, Shabir A.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
- Artiklar i publikationen
-
PLOS ONE
- Av lärosätet
-
Umeå universitet