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Type X collagen, a ...
Type X collagen, a natural component of mouse articular cartilage : association with growth, aging, and osteoarthritis.
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- Eerola, Iiro (författare)
- Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland
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- Salminen, Heli (författare)
- Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland
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- Lammi, Pirkko (författare)
- Department of Anatomy, University of Kuopio, Kuopio, Finland
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- Lammi, Mikko, 1961- (författare)
- Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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- von der Mark, Klaus (författare)
- Institute of Experimental Medicine, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany
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- Vuorio, Eero (författare)
- Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland
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- Säämänen, Anna-Marja (författare)
- Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland
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(creator_code:org_t)
- John Wiley & Sons, 1998
- 1998
- Engelska.
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Ingår i: Arthritis and Rheumatism. - : John Wiley & Sons. - 0004-3591 .- 1529-0131. ; 41:7, s. 1287-1295
- Relaterad länk:
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http://onlinelibrary...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To perform a systematic study on the production and deposition of type X collagen in developing, aging, and osteoarthritic (OA) mouse articular cartilage.METHODS: Immunohistochemistry was employed to define the distribution of type X collagen and Northern analyses to determine the messenger RNA levels as an indicator of the synthetic activity of the protein.RESULTS: Type X collagen was observed in the epiphyseal and articular cartilage of mouse knee joints throughout development and growth. Type X collagen deposition in the transitional zone of articular cartilage became evident toward cessation of growth, at the age of 2-3 months. The most intense staining for type X collagen was limited to the tidemark, the border between uncalcified and calcified cartilage. Northern analysis confirmed that the type X collagen gene is also transcribed by articular cartilage chondrocytes. Intense immunostaining was observed in the areas of OA lesions, specifically, at sites of osteophyte formation and surface fibrillation. Type X collagen deposition was also seen in degenerating menisci.CONCLUSION: This study demonstrates that type X collagen is a natural component of mouse articular cartilage throughout development, growth, and aging. This finding and the deposition of type X collagen at sites of OA lesions suggest that type X collagen may have a role in providing structural support for articular cartilage.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Articular cartilge
- mouse
- type X collagen
- growth
- ageing
- biokemi
- Biochemistry
- molekylärbiologi
- Molecular Biology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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