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Can echocardiograph...
Can echocardiography and ECG discriminate hereditary transthyretin V30M amyloidosis from hypertrophic cardiomyopathy?
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- Gustavsson, Sandra (author)
- Umeå universitet,Klinisk fysiologi,Kardiologi,Heart Centre
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- Granåsen, Gabriel (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Grönlund, Christer (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Centrum för medicinsk teknik och fysik (CMTF)
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- Wiklund, Urban (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Mörner, Stellan (author)
- Umeå universitet,Kardiologi
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- Henein, Michael (author)
- Umeå universitet,Kardiologi
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- Suhr, Ole B (author)
- Umeå universitet,Medicin
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- Lindqvist, Per (author)
- Umeå universitet,Klinisk fysiologi,Kardiologi
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(creator_code:org_t)
- 2015-06-24
- 2015
- English.
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In: Amyloid. - : Informa UK Limited. - 1350-6129 .- 1744-2818. ; 22:3, s. 163-170
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Objective: Hereditary transthyretin (ATTR) amyloidosis with increased left ventricular wall thickness could easily be misdiagnosed by echocardiography as hypertrophic cardiomyopathy (HCM). Our aim was to create a diagnostic tool based on echocardiography and ECG that could optimise identification of ATTR amyloidosis. Methods: Data were analysed from 33 patients with biopsy proven ATTR amyloidosis and 30 patients with diagnosed HCM. Conventional features from ECG were acquired as well as two dimensional and Doppler echocardiography, speckle tracking derived strain and tissue characterisation analysis. Classification trees were used to select the most important variables for differentiation between ATTR amyloidosis and HCM. Results: The best classification was obtained using both ECG and echocardiographic features, where a QRS voltage >30 mm was diagnostic for HCM, whereas in patients with QRS voltage <30 mm, an interventricular septal/posterior wall thickness ratio (IVSt/PWt) >1.6 was consistent with HCM and a ratio <1.6 supported the diagnosis of ATTR amyloidosis. This classification presented both high sensitivity (0.939) and specificity (0.833). Conclusion: Our study proposes an easily interpretable classification method for the differentiation between HCM and increased left ventricular myocardial thickness due to ATTR amyloidosis. Our combined echocardiographic and ECG model could increase the ability to identify ATTR cardiac amyloidosis in clinical practice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiac amyloidosis
- classification tree
- echocardiography
- electrocardiography
- hypertrophic rdiomyopathy
- hypertrophy
Publication and Content Type
- ref (subject category)
- art (subject category)
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