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Self-reported memor...
Self-reported memory failures : associations with future dementia in a population-based study with long-term follow-up
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- Rönnlund, Michael (författare)
- Umeå universitet,Institutionen för psykologi
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- Sundström, Anna (författare)
- Umeå universitet,Institutionen för psykologi,Enheten för demografi och åldrandeforskning (CEDAR)
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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- Nilsson, Lars-Göran (författare)
- Stockholms universitet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Aging Research Center, Karolinska Institutet, Stockholm, Sweden,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden
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(creator_code:org_t)
- 2015-08-17
- 2015
- Engelska.
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Ingår i: Journal of The American Geriatrics Society. - : Wiley-Blackwell. - 0002-8614 .- 1532-5415. ; 63:9, s. 1766-1773
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: To examine the association between self-reported memory failures and incident dementia in individuals aged 60 and older.DESIGN: Longitudinal, community based.SETTING: Betula Prospective Cohort Study, a population-based study in Umea, Sweden.PARTICIPANTS: Individuals with a mean age of 71.5 +/- 8.8 (range 60-90) (N = 1,547).MEASUREMENTS: Participants rated the frequency of everyday memory failures using the 16-item Prospective and Retrospective Memory Questionnaire (PRMQ) and underwent objective memory testing at baseline. Participant self-reports of complaints of poor memory by family and friends were evaluated. Dementia status was followed-up for 10 to 12 years.RESULTS: Over the study period, 225 participants developed dementia (132 with Alzheimer's disease (AD)). In Cox proportional hazard regression models adjusted for demographic factors, PRMQ z-scores predicted incident dementia (hazard ratio (HR) = 1.21 for all-cause dementia; HR = 1.25 for AD, Ps < .01). The significant associations remained when depressive symptoms and objective memory performance were adjusted for, when low performers on objective memory (= 1 standard deviations below the age group mean) were excluded, and in analyses with delayed entry (survival time = 5 years). Similar patterns were observed for the prospective and retrospective subscales, although including how often participants self-reported that others complained about their poor memory eliminated the association between PRMQ scores and dementia and itself emerged as a significant predictor.CONCLUSION: Self-reported memory failure predicted future dementia or AD independent of objective memory performance. Subjective reports of complaints by family and friends appear to be an even more-important indicator of preclinical impairments, and physicians should not ignore them, even in the absence of objective memory deficits.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- subjective memory
- objective memory
- dementia
- Alzheimer's disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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