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Hypothalamus-Pituit...
Hypothalamus-Pituitary-Adrenal Axis Hypersuppression Is Associated with Gastrointestinal Symptoms in Major Depression
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- Karling, Pontus (författare)
- Umeå universitet,Medicin
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- Wikgren, Mikael (författare)
- Umeå universitet,Medicin,Psykiatri
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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- Norrback, Karl-Fredrik (författare)
- Umeå universitet,Psykiatri
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(creator_code:org_t)
- The Korean Society of Neurogastroenterology and Motility, 2016
- 2016
- Engelska.
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Ingår i: Journal of neurogastroenterology and motility. - : The Korean Society of Neurogastroenterology and Motility. - 2093-0879 .- 2093-0887. ; 22:2, s. 292-303
- Relaterad länk:
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http://www.jnmjourna...
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https://urn.kb.se/re...
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- Background/Aims: Gastrointestinal symptoms and hypothalamus-pituitary-adrenal (HPA) axis dysfunction are frequently observed in patients with major depression. The primary aim of the study was to investigate the relationship between HPA-axis function and self-perceived functional gastrointestinal symptoms in major depression.Methods: Patients with major depression (n = 73) and controls representative of the general population (n = 146) underwent a weight-adjusted very low dose dexamethasone suppression test (DST). Patients and controls completed the Gastrointestinal Symptom Rating Scale-Irritable Bowel Syndrome (GSRS-IBS) and the Hospital Anxiety Depression Scale. Medical records of the patients were screened over a ten year period for functional gastrointestinal disorder and pain conditions.Results: Patients with high GSRS-IBS scores (above median) exhibited HPA-axis hypersuppression more often than controls (defined by the lowest 10% cutoff of the post-DST cortisol values among controls, adjusted OR 7.25, CI 1.97-26.7) whereas patients with low GSRS-IBS scores did not differ from controls concerning their post-DST cortisol values. Patients who had consulted primary care for functional gastrointestinal disorder (P= 0.039), lumbago (P = 0.006) and chronic multifocal pain (P= 0.057) also exhibited an increased frequency of hypersuppression.Conclusions: HPA-axis hypersuppression is associated with functional gastrointestinal symptoms in patients with major depression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Depression
- Dexamethasone
- Hypocortisolism
- Hypothalamo-hypophyseal system
- Irritable bowel syndrome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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