Drosophila hemopoiesis and cellular immunity

• In Drosophila melanogaster larvae, three classes of circulating cellular immune surveillance cells (hemocytes) can be identified: plasmatocytes, crystal cells, and lamellocytes. Plasmatocytes are profiessional phagocytes most similar to the mammalian monocyte/macrophage lineage and make up similar to 95% of circulating hemocytes. The other similar to 5% of circulating hemocytes consists of crystal cells, which secrete components necessary for the melanization of invading organisms, as well as for wound repair. A third cell type known as lamellocytes are rarely seen in healthy larvae and are involved in the encapsulation of invading pathogens. There are no obvious mammalian counterparts for crystal cells or lamellocytes, and there is no equivalent to the lymphoid lineage in insects. In this review, I will discuss what is currently known about Drosophila hemopoiesis and the cellular immune response and where possible compare it to vertebrate mechanisms.

Ämnesord

NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

Nyckelord

larval hematopoiesis

Anopheles Gambiae

genetic analysis

growth-factor

Runx factors

blood-cells

receptor

phagocytosis

migration

identification

Publikations- och innehållstyp

ref (ämneskategori)

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