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Microwave assisted ...
Microwave assisted synthesis and cytotoxic activity evaluations of new benzimidazole derivatives
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Bui, Hue Thi Buu (författare)
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Ha, Quy Thi Kim (författare)
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Oh, Won Keun (författare)
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- Vo, Duy Duc (författare)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Kemiska institutionen
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Chau, Yen Nguyen Tram (författare)
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Tu, Cuc Thi Kim (författare)
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Pham, Em Canh (författare)
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Tran, Phuong Thao (författare)
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Tran, Loan Thi (författare)
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Mai, Hieu Van (författare)
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- Engelska.
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Ingår i: Tetrahedron Letters. - : Elsevier. - 0040-4039 .- 1359-8562. ; 57:8, s. 887-891
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Twelve new 2-quinolizinylbenzimidazole and 2-naphthalylbenzimidazole derivatives with various 5- and 6-positioned substituents (aza, H, CH3, Cl, NO2, NH2, OCH3), have been synthesized in moderate to excellent yields via the condensation of 4-oxo-4H-quinolizinecarbaldehyde or naphthalenecarbaldehyde with substituted o-phenylenediamines, o-nitroaniline, and 2,3-pyridinediamine using sodium metabisulfite or sodium hydrosulfite under microwave irradiation. The new benzimidazole derivatives were screened for their cytotoxic activity against the human breast cancer cell line (MCF-7). The results showed on one hand that 2-(substituted quinolizinyl)-1H-benzimidazoles (12b–f) were less active (3–6 fold) than the positive control Tamoxifen (CC50 = 6.52 μM), and on the other hand, among the 2-(substituted naphthalyl)-1H-benzimidazoles series (13a–f), compounds 6,7,8-trimethoxy-3-(5-chloro-1H-benzo[d]imidazol-2-yl)naphthalen-1-ol (13c) (CC50 = 7.48 μM) and 6,7,8-trimethoxy-3-(5-methoxy-1H-benzo[d]imidazol-2-yl)naphthalen-1-ol (13f) (CC50 = 6.43 μM) were found to be as active as Tamoxifen.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- 4-Oxo-4H-quinolizine
- Naphthalene
- Benzimidazole
- Stobbe condensation
- Microwave assisted ganic synthesis
- Human breast cancer cell line
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Bui, Hue Thi Buu
-
Ha, Quy Thi Kim
-
Oh, Won Keun
-
Vo, Duy Duc
-
Chau, Yen Nguyen ...
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Tu, Cuc Thi Kim
-
visa fler...
-
Pham, Em Canh
-
Tran, Phuong Tha ...
-
Tran, Loan Thi
-
Mai, Hieu Van
-
visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Organisk kemi
- Artiklar i publikationen
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Tetrahedron Lett ...
- Av lärosätet
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Umeå universitet