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High expression of ...
High expression of podoplanin in squamous cell carcinoma of the tongue occurs predominantly in patients ≤ 40 years but does not correlate with tumour spread
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- Sgaramella, Nicola (författare)
- Umeå universitet,Patologi,Second University of Naples, Multidisciplinary Department of Medical, Surgical and Dental Specialties, Naples, Italy; Department of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy,Univ Naples Federico II, Dept Neurosci Reprod & Dent Sci, Naples, Italy
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- Lindell Jonsson, Eva (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar,Göran Laurell
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- Boldrup, Linda (författare)
- Umeå universitet,Patologi
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- Califano, Luigi (författare)
- University of Naples, Italy,Univ Naples Federico II, Dept Neurosci Reprod & Dent Sci, Naples, Italy
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- Coates, Philip J (författare)
- University of Dundee, UK
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- Tartaro, Gianpaolo (författare)
- Second University of Naples, Italy
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- Lo Muzio, Lorenzo (författare)
- University of Foggia, Italy
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- Fåhraeus, Robin (författare)
- University Paris Diderot, INSERM UMRS1162, Paris, France; RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic
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- Colella, Giuseppe (författare)
- Second University of Naples, Italy
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- Dell'Aversana Orabona, Giovanni (författare)
- University of Naples, Italy
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- Loljung, Lotta (författare)
- Umeå universitet,Patologi
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- Santagata, Mario (författare)
- Second University of Naples, Italy
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- Rossiello, Riccardo (författare)
- Seconda Universita’ Degli Studi di Napoli, Italy
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- Wilms, Torben (författare)
- Umeå universitet,Öron- näs- och halssjukdomar
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- Danielsson, Karin (författare)
- Umeå universitet,Institutionen för odontologi
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- Laurell, Göran (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Nylander, Karin (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2015-10-09
- 2016
- Engelska.
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Ingår i: The Journal of Pathology: Clinical Research. - : John Wiley & Sons. - 2056-4538. ; 2:1, s. 3-8
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://onlinelibrar...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- More than 30% of patients with squamous cell carcinoma (SCC) of the mobile tongue have clinically undetectable lymph node metastasis. Tumour cells can spread as single cells or collectively. A protein known to play a role in both processes is podoplanin, which is expressed in endothelial cells not only in lymph vessels but also in some aggressive tumours with high invasive and metastatic potential. Here we studied samples from 129 patients with primary SCC of the tongue for expression of podoplanin using immunohistochemistry. mRNA levels were analysed in another 27 cases of tongue SCC with adjacent clinically tumour-free tongue tissue and 14 tongue samples from healthy donors. Higher levels of podoplanin were seen in tumours compared to both normal tongue and clinically normal tongue in the tumour vicinity. No association was found between levels of podoplanin, presence of lymph node metastases or other clinical factors. Patients aged 40 or less were more likely to express high levels of podoplanin protein compared to older patients (p 50.027). We conclude that levels of podoplanin in primary tongue SCCs are not associated with lymph node metastases. However, tongue SCCs arising in young patients (40 years of age) are more likely to express high levels of podoplanin than tongue SCCs that arise in the more elderly. The data suggest that podoplanin has a distinctive role in young patients, who are known to have a poor prognosis: these patients may, therefore, benefit from podoplanin inhibitory therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Nyckelord
- squamous cell carcinoma
- tongue
- podoplanin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Sgaramella, Nico ...
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Lindell Jonsson, ...
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Boldrup, Linda
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Califano, Luigi
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Coates, Philip J
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Tartaro, Gianpao ...
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visa fler...
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Lo Muzio, Lorenz ...
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Fåhraeus, Robin
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Colella, Giusepp ...
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Dell'Aversana Or ...
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Loljung, Lotta
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Santagata, Mario
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Rossiello, Ricca ...
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Wilms, Torben
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Danielsson, Kari ...
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Laurell, Göran
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Nylander, Karin
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Oto rhino laryng ...
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The Journal of P ...
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Umeå universitet
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Uppsala universitet