Hematologic Diseases : Autoimmune Hemolytic Anemia and Immune Thrombocytopenic Purpura

• SummaryAutoinimune destruction of circularing blood cells in autoummunc hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP) is often seen in autoirnnsune diseases and lymhoid malignancies. Erythrocytes or platelets that arc recognized by autoantibodues are rapidly phagocytosed by rnacrophages. Although much is known about the mechanisms behind macrophage-mediated destruction of sensitized blood cells, 1ess is known about the genetics behind AIHA and ITP. We here review what is known about the ethiology of Al 1-IA and lip, with particular emphasis on the role olgenetic factors behind auroanribody production. 1 cell activation and apoptosis, and Fcy receptor polymorphisms. The importance of inhibitory regulation oi rnacrophagcs through CD47IS[RPa interaction, and its significance for autoirnmune hemarological disease is also discussed.

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vet (subject category)

kap (subject category)