Sökning: id:"swepub:oai:DiVA.org:umu-127718" >
Longitudinal Eviden...
Longitudinal Evidence for Dissociation of Anterior and Posterior MTL Resting-State Connectivity in Aging : Links to Perfusion and Memory
-
- Salami, Alireza (författare)
- Karolinska Institutet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi,Aging Research Center, Karolinska Institutet and Stockholm University, SE-113 30, Stockholm, Sweden
-
- Wåhlin, Anders (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Radiofysik
-
- Kaboodvand, Neda (författare)
- Karolinska Institutet,Stockholms universitet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Aging Research Center, Karolinska Institutet and Stockholm University, SE-113 30, Stockholm, Sweden,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden
-
visa fler...
-
- Lundquist, Anders (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi
-
- Nyberg, Lars (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi,Diagnostisk radiologi
-
visa färre...
-
(creator_code:org_t)
- 2016-08-13
- 2016
- Engelska.
-
Ingår i: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 26:10, s. 3953-3963
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Neuroimaging studies of spontaneous signal fluctuations as measured by resting-state functional magnetic resonance imaging have revealed age-related alterations in the functional architecture of brain networks. One such network is located in the medial temporal lobe (MTL), showing structural and functional variations along the anterior-posterior axis. Past cross-sectional studies of MTL functional connectivity (FC) have yielded discrepant findings, likely reflecting the fact that specific MTL subregions are differentially affected in aging. Here, using longitudinal resting-state data from 198 participants, we investigated 5-year changes in FC of the anterior and posterior MTL. We found an opposite pattern, such that the degree of FC within the anterior MTL declined after age 60, whereas elevated FC within the posterior MTL was observed along with attenuated posterior MTL-cortical connectivity. A significant negative change-change relation was observed between episodic-memory decline and elevated FC in the posterior MTL. Additional analyses revealed age-related cerebral blood flow (CBF) increases in posterior MTL at the follow-up session, along with a positive relation of elevated FC and CBF, suggesting that elevated FC is a metabolically demanding alteration. Collectively, our findings indicate that elevated FC in posterior MTL along with increased local perfusion is a sign of brain aging that underlie episodic-memory decline.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Nyckelord
- episodic memory
- functional connectivity
- longitudinal
- anterior and posterior MTL
- perfusion
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas