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Synthesis of 2-Subs...
Synthesis of 2-Substituted Pyridines via a Regiospecific Alkylation, Alkynylation, and Arylation of Pyridine N-Oxides
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- Andersson, Hans (författare)
- Umeå universitet,Kemiska institutionen
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- Almqvist, Fredrik (författare)
- Umeå universitet,Kemiska institutionen
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Olsson, Roger (författare)
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(creator_code:org_t)
- 2007-03-01
- 2007
- Engelska.
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Ingår i: Organic Letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 9:7, s. 1335-7
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Sequential addition of Grignard reagents to pyridine N-oxides in THF at room temperature followed by treatment with acetic anhydride at 120 C afforded 2-substituted pyridines in good to high yields. Furthermore, by exchanging acetic anhydride for DMF in the second step, 2-substituted pyridine N-oxides were obtained, as intermediates suitable for addition of a second Grignard reagent for the synthesis of 2,6-disubstituted pyridines.
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