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Human Chorionic Gon...
Human Chorionic Gonadotropin Does Not Correlate with Risk for Maternal Breast Cancer : Results from the Finnish Maternity Cohort
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Fortner, Renée T (författare)
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Schock, Helena (författare)
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Kaaks, Rudolf (författare)
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- Lehtinen, Matti (författare)
- Karolinska Institutet
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Pukkala, Eero (författare)
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- Lakso, Hans-Åke (författare)
- Umeå universitet,Klinisk kemi
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Tanner, Minna (författare)
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Kallio, Raija (författare)
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Joensuu, Heikki (författare)
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Korpela, Jaana (författare)
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Toriola, Adetunji T (författare)
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- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning
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- Grankvist, Kjell (författare)
- Umeå universitet,Klinisk kemi
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Zeleniuch-Jacquotte, Anne (författare)
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Toniolo, Paolo (författare)
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- Lundin, Eva (författare)
- Umeå universitet,Patologi
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Surcel, Heljä-Marja (författare)
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 77:1, s. 134-141
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Human chorionic gonadotropin (hCG) is necessary for the maintenance of early pregnancy and promotes normal breast cell differentiation. Administered hCG reduces risk of carcinogen-induced breast cancer in animal models, and higher circulating hCG concentrations were associated with significantly lower long-term risk of breast cancer in a prior nested case-control study. In this study, we investigated early-pregnancy hCG concentrations and subsequent breast cancer risk. We conducted a nested case-control study with 1,191 cases and 2,257 controls (matched on age and date at blood collection) in the Finnish Maternity Cohort, a cohort with serum samples from 98% of pregnancies registered in Finland since 1983. This study included women with a serum sample collected early (<140 days gestation) in their first pregnancy resulting in a live, term birth. Breast cancer cases were identified via the Finnish Cancer Registry. Age at breast cancer diagnosis ranged from 22 to 58 years (mean: 41 years). hCG was measured using a solid-phase competitive chemiluminescence assay. Odds ratios (OR) were calculated using conditional logistic regression. We observed no association between hCG and breast cancer risk, overall [Quartile 4 vs. 1, OR, 1.14; 95% confidence interval (CI), 0.94-1.39], by estrogen and progesterone receptor status, or by ages at first-term birth or diagnosis. Associations did not differ by time between pregnancy and diagnosis (e.g., <5 years, ORQ4 vs. Q1, 1.10; 95% CI, 0.64-1.89; ≥15 years, ORQ4 vs. Q1, 1.36; 95% CI, 0.86-2.13; pheterogeneity = 0.62). This large prospective study does not support an inverse relationship between early pregnancy serum hCG concentrations and breast cancer risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Fortner, Renée T
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Schock, Helena
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Kaaks, Rudolf
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Lehtinen, Matti
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Pukkala, Eero
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Lakso, Hans-Åke
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visa fler...
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Tanner, Minna
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Kallio, Raija
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Joensuu, Heikki
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Korpela, Jaana
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Toriola, Adetunj ...
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Hallmans, Göran
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Grankvist, Kjell
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Zeleniuch-Jacquo ...
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Toniolo, Paolo
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Lundin, Eva
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Surcel, Heljä-Ma ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancer Research
- Av lärosätet
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Umeå universitet
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Karolinska Institutet