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HSV presence in bra...
HSV presence in brains of individuals without dementia : the TASTY brain series
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- Olsson, Jan (författare)
- Umeå universitet,Virologi
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- Lövheim, Hugo (författare)
- Umeå universitet,Geriatrik
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- Honkala, Emma (författare)
- Umeå universitet,Virologi
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Karhunen, Pekka J. (författare)
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- Elgh, Fredrik (författare)
- Umeå universitet,Virologi
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Kok, Eloise H. (författare)
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(creator_code:org_t)
- 2016-01-01
- 2016
- Engelska.
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Ingår i: Disease Models and Mechanisms. - : The Company of Biologists. - 1754-8403 .- 1754-8411. ; 9:11, s. 1349-1355
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (A beta) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had A beta aggregations, most of those with A beta aggregations did not have HSV present in the brain tissue.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Herpes simplex virus
- Amyloid beta aggregations
- Alzheimer's disease
- PCR detection
- Human brain tissue
- Paraffin-embedded samples
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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