Sökning: id:"swepub:oai:DiVA.org:umu-139007" >
Meta-Analysis of th...
Meta-Analysis of the Association Between Phosphodiesterase Inhibitors (PDE5Is) and Risk of Melanoma
-
- Loeb, Stacy (författare)
- NYU, Dept Urol, New York, NY USA.;NYU, New York, NY USA.;Manhattan VA, New York, NY USA.
-
- Ventimiglia, Eugenio (författare)
- Umeå universitet,Urologi och andrologi,Division of Experimental Oncology, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; Universita Vita-Salute San Raffaele, Milan, Italy,IRCCS Osped San Raffaele, Div Expt Oncol, Unit Urol, URI, Milan, Italy.;Univ Vita Salute San Raffaele, Milan, Italy.;Umea Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden.
-
- Salonia, Andrea (författare)
- IRCCS Osped San Raffaele, Div Expt Oncol, Unit Urol, URI, Milan, Italy.;Univ Vita Salute San Raffaele, Milan, Italy.
-
visa fler...
-
- Folkvaljon, Yasin (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
-
- Stattin, Pär (författare)
- Uppsala universitet,Umeå universitet,Urologi och andrologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden,Urologkirurgi,Umea Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden.
-
visa färre...
-
NYU, Dept Urol, New York, NY USA;NYU, New York, NY USA.;Manhattan VA, New York, NY USA. Urologi och andrologi (creator_code:org_t)
- 2017-05-19
- 2017
- Engelska.
-
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 109:8
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://academic.oup...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- The US Food and Drug Administration recently announced the need to evaluate the association between PDE5is and melanoma. We performed a meta-analysis on the association between PDE5i and melanoma using random effects models and examined whether it met Hill's criteria for causality. A systematic search of Medline, EMBASE, and the Cochrane Library from 1998 to 2016 identified three case-control studies and two cohort studies, including a total of 866 049 men, of whom 41 874 were diagnosed with melanoma. We found a summary estimate indicating an increased risk of melanoma in PDE5i users (relative risk = 1.12, 95% confidence interval = 1.02 to 1.23). However, there was no difference in risk between men with low and high exposure to PDE5i, and risk was higher for in situ melanoma than localized and high-risk melanoma, suggesting a lack of dose response and biological gradient. PDE5i use was also associated with basal cell cancer, suggesting a lack of specificity and likely confounding by ultraviolet exposure. Thus, although this meta-analysis found a statistically significant association between PDE5i and melanoma, it did not satisfy Hill's criteria for causality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas