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Dysregulation of th...
Dysregulation of the autonomic nervous system can be a link between visceral adiposity and insulin resistance
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- Lindmark, Stina (författare)
- Umeå universitet,Medicin
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Lönn, Lars (författare)
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- Wiklund, Urban (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Tufvesson, Magnus (författare)
- Umeå universitet,Medicin
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- Olsson, Tommy (författare)
- Umeå universitet,Medicin
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- Eriksson, Jan W (författare)
- Uppsala universitet,Umeå universitet,Medicin,Endokrin diabetes och metabolism
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(creator_code:org_t)
- 2012-09-06
- 2005
- Engelska.
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Ingår i: Obesity Research. - : Wiley. - 1071-7323 .- 1550-8528. ; 13:4, s. 717-728
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To evaluate the interplay among abdominal adipose tissue distribution, the cortisol axis, the autonomic nervous system, and insulin resistance. RESEARCH METHODS AND PROCEDURES: Two age-, sex-, and BMI-matched groups were studied. Fifteen subjects were first-degree relatives of patients with type 2 diabetes (R), and 15 had no family history of diabetes (controls, C). A hyperinsulinemic euglycemic clamp, cortisol measurements, and analysis of heart rate variability (HRV) were performed. Computed tomography was performed in a subgroup (n = 9 + 9) to determine abdominal adipose tissue distribution. RESULTS: R tended to be less insulin-sensitive than C (M value 9.2 +/- 1.0 vs 10.3 +/- 0.7 mg/kg per minute, not significant). Stimulation with tetracosactin or corticotropin releasing hormone yielded lower peak serum cortisol levels in R (p = 0.03 and p = 0.06, respectively). The amount of visceral abdominal fat (VAT) tended to be greater in R. In all subjects, VAT was negatively correlated to insulin sensitivity (r = -0.93, p < 0.001). There was a positive association between VAT and resting heart rate (r = 0.70, p = 0.003) and sympathetic/parasympathetic ratio in HRV assessment after tilt (r = 0.53, p = 0.03). Subcutaneous abdominal tissue was not associated with insulin sensitivity or any of the hormonal or HRV assessments. DISCUSSION: Subjects genetically predisposed for type 2 diabetes had a tendency toward a larger amount of VAT and to lower insulin sensitivity compared with control subjects. The amount of visceral fat was strongly associated with insulin resistance and signs of a high ratio of sympathetic vs. parasympathetic reactivity. A large amount of visceral fat may act in concert with sympathetic/parasympathetic imbalance to promote the development of insulin resistance, and this may be partly independent of genetic background.
Nyckelord
- Type 2 diabetes
- family history
- insulin resistance
- cortisol axis
- visceral fat
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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