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Dietary Polyphenols...
Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC)
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- Lu, Yunxia (författare)
- University of California, Irvine
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- Zamora-Ros, Raul (författare)
- International Agency for Research on Cancer, World Health Organization
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- Chan, Simon (författare)
- University of East Anglia
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- Cross, Amanda J. (författare)
- Imperial College London
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- Ward, Heather (författare)
- Imperial College London
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- Jakszyn, Paula (författare)
- Bellvitge University Hospital-IDIBELL
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- Luben, Robert (författare)
- University of Cambridge
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- Opstelten, Jorrit L. (författare)
- University Medical Center Utrecht
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- Oldenburg, Bas (författare)
- University Medical Center Utrecht
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- Hallmans, Göran (författare)
- Umeå University,Umeå universitet,Näringsforskning
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- Karling, Pontus (författare)
- Umeå University,Umeå universitet,Medicin
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- Grip, Olof (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Key, Timothy (författare)
- University of Oxford
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- Bergmann, Manuela M. (författare)
- German Institute of Human Nutrition
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Overvad, Kim (författare)
- Aarhus University
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Masala, Giovanna (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- Racine, Antoine (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Carbonnel, Franck (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Boutron-Ruault, Marie-Christine (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Andersen, Vibeke (författare)
- University of Southern Denmark
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- Olsen, Anja (författare)
- Danish Cancer Society
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Trichopoulou, Antonia (författare)
- WHO Collaborating Center for Food and Nutrition Policies, Greece
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- Scalbert, Augustin (författare)
- International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (författare)
- Imperial College London
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- Hart, Andrew R. (författare)
- University of East Anglia
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2017
- 2017
- Engelska.
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Ingår i: Inflammatory Bowel Diseases. - : Lippincott Williams & Wilkins. - 1078-0998 .- 1536-4844. ; 23:12, s. 2072-2082
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.Methods: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case–control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC.Results: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD ( P trend = 0.17) or UC ( P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR 3rd versus 1st quartile = 0.33; 95% confidence interval, 0.15–0.69) and there was an inverse trend across quartiles ( P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR 4th versus 1st quartile = 0.40; 95% confidence interval, 0.20–0.82) with an inverse trend across quartiles ( P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance.Conclusions: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- polyphenols
- Crohn's diseases
- ulcerative colitis
- antioxidants
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lu, Yunxia
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Zamora-Ros, Raul
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Chan, Simon
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Cross, Amanda J.
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Ward, Heather
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Jakszyn, Paula
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visa fler...
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Luben, Robert
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Opstelten, Jorri ...
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Oldenburg, Bas
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Hallmans, Göran
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Karling, Pontus
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Grip, Olof
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Key, Timothy
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Bergmann, Manuel ...
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Boeing, Heiner
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Overvad, Kim
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Palli, Domenico
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Masala, Giovanna
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Khaw, Kay-Tee
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Racine, Antoine
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Carbonnel, Franc ...
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Boutron-Ruault, ...
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Andersen, Vibeke
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Olsen, Anja
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Tjonneland, Anne
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Kaaks, Rudolf
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Tumino, Rosario
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Trichopoulou, An ...
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Scalbert, August ...
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Riboli, Elio
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Hart, Andrew R.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Inflammatory Bow ...
- Av lärosätet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet