Fatal Puumala Hantavirus Disease : Involvement of Complement Activation and Vascular Leakage in the Pathobiology

• The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

case-fatality rate

complement

hantavirus

Puumala virus

vascular leakage

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)