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Risk of ischemic he...
Risk of ischemic heart disease after radiotherapy for ductal carcinoma in situ
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- Wadsten, Charlotta (författare)
- Uppsala universitet,Umeå universitet,Kirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Department of Surgery, Sundsvall Hospital, Sundsvall, Sweden,Institutionen för kirurgiska vetenskaper,Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden;Sundsvall Hosp, Dept Surg, Sundsvall, Sweden
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- Wennstig, A.-K (författare)
- Uppsala universitet,Umeå universitet,Kirurgi,Institutionen för kirurgiska vetenskaper
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- Garmo, H. (författare)
- Kings Coll London, Fac Life Sci & Med, Sect Canc Epidemiol & Populat Hlth, London, England;Uppsala Univ, Reg Canc Ctr, Uppsala Univ Hosp, Uppsala, Sweden
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- Nilsson, Greger (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Visby Hosp, Dept Oncol, Visby, Sweden;Gavle Cent Hosp, Dept Oncol, Gavle, Sweden
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- Blomqvist, Carl (författare)
- Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland;Orebro Univ Hosp, Dept Oncol, Orebro, Sweden
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- Holmberg, Lars (författare)
- Uppsala universitet,Endokrinkirurgi,Kings Coll London, Fac Life Sci & Med, Sect Canc Epidemiol & Populat Hlth, London, England
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- Fredriksson, Irma (författare)
- Karolinska Institutet
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- Wärnberg, Fredrik (författare)
- Uppsala universitet,Endokrinkirurgi
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- Sund, Malin (författare)
- Umeå universitet,Kirurgi,Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden
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(creator_code:org_t)
- 2018-05-05
- 2018
- Engelska.
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Ingår i: Breast Cancer Research and Treatment. - : Springer. - 0167-6806 .- 1573-7217. ; 171:1, s. 95-101
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose: The use of adjuvant radiotherapy (RT) in the management of ductal carcinoma in situ (DCIS) is increasing. Left-sided breast irradiation may involve exposure of the heart to ionising radiation, increasing the risk of ischemic heart disease (IHD). We examined the incidence of IHD in a population-based cohort of women with DCIS.Methods: The Breast Cancer DataBase Sweden (BCBase) cohort includes women registered with invasive and in situ breast cancers 1992-2012 and age-matched women without a history of breast cancer. In this analysis, 6270 women with DCIS and a comparison cohort of 31,257 women were included. Through linkage with population-based registers, data on comorbidity, socioeconomic status and incidence of IHD was obtained. Hazard ratios (HR) for IHD with 95% confidence intervals (CI) were analysed.Results: Median follow-up time was 8.8 years. The risk of IHD was not increased for women with DCIS versus women in the comparison cohort (HR 0.93; 95% CI 0.82-1.06), after treatment with radiotherapy versus surgery alone (HR 0.77; 95% CI 0.60-0.98) or when analysing RT by laterality (HR 0.85; 95% CI 0.53-1.37 for left-sided versus right-sided RT).Conclusions: The risk of IHD was lower for women with DCIS allocated to RT compared to non-irradiated women and to the comparison cohort, probably due to patient selection. Comparison of RT by laterality did not show any over-risk for irradiation of the left breast.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- ductal carcinoma in situ
- radiotherapy
- ischemic heart disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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